Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Rezaeikia Zahra; SAEIDI SAR SAKINEH; Malakijoo Noorolhoda; MOUSAVI ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2019 | Volume:29 | Issue:2 Page(s): 125-130

Download Full-Text

Persian Verion

View:

446

Download:

Cites:

Information Journal Paper

Title

Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats

Author(s)

Rezaeikia Zahra | SAEIDI SAR SAKINEH | Malakijoo Noorolhoda | MOUSAVI ZAHRA | Issue Writer Certificate

Keywords

F.parvifloraQ2

vincristineQ3

HepatotoxicityQ1

RatQ2

Abstract

Background: Hepatoprotective effects of Fumaria parviflora have been approved in pharmaceutical and chemical toxicity models. Given the importance of the vincristine-induced Hepatotoxicity during chemotherapy, the aim of this study was to investigate the potential hepatoprotective effects of F. parviflora extract on vincristine induced toxicity in adult male Rats. Materials and methods: In this experimental study, the Rats (n=42) were divided into 7 groups: 1) Sham group, 2) vehicle group, 3) vincristine group (VCR) (0. 5 mg/kg, i. p. ), 4) F. parviflora extract (300 mg/kg, p. o. ), 5) F. parviflora extract (500 mg/kg, p. o. ), 6) Pretreatment group: F. parviflora extract (300mg/kg for 10 days, p. o. ) + VCR (0. 5 mg/kg, i. p. ) on 9th and 10th days of the experiment, and 7) Pretreatment group: F. parviflora extract (500mg/kg for 10 days, p. o. ) +VCR (0. 5 mg/kg, i. p. ) on 9th and 10th days of the experiment. Serum values of AST, ALT, ALP and malondialdehyde (MDA) were measured. Data were analyzed by one way ANOVA using prism software. Results: F. parviflora extract with dose of 500 mg/kg markedly decreased ALT hepatic enzyme level caused by vincristine (P<0. 01). In addition, the dose of 300 mg/kg could not decrease the elevated liver enzymes, including ALP, ALT and AST and also MDA levels. Conclusion: Hepatoprotective effects of F. parviflora extract were not considerable in pretreatment groups.

Cites

No record.

References

No record.

Cite

APA: Copy

Rezaeikia, Zahra, SAEIDI SAR, SAKINEH, & Malakijoo, Noorolhoda. (2019). Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 29(2 ), 125-130. SID. https://sid.ir/paper/98931/en

Vancouver: Copy

Rezaeikia Zahra, SAEIDI SAR SAKINEH, Malakijoo Noorolhoda. Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2019;29(2 ):125-130. Available from: https://sid.ir/paper/98931/en

IEEE: Copy

Zahra Rezaeikia, SAKINEH SAEIDI SAR, and Noorolhoda Malakijoo, “Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 29, no. 2 , pp. 125–130, 2019, [Online]. Available: https://sid.ir/paper/98931/en

Related Journal Papers