Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury

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Toktay Erdem; Bal Tastan Tugba; Gurbuz Muhammet Ali; Erbas Elif; Demir Ozlem; Anil Ugan Rustem

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2022 | Volume:25 | Issue:2 Page(s): 173-178

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Title

Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury

Author(s)

Keywords

Astaxanthin

Ischemia

Ovary

Oxidative stress

Rat

Reperfusion

Abstract

Objective(s): We thought that Astaxanthin (ASX) might be a protective agent in Oxidative stress damage that develops against Ischemia and Reperfusion injury in the Rat Ovary. Materials and Methods: The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100, I/R (Ischemia/Reperfusion), I/R+ ASX50, and I/R+ ASX100. Vascular clamps were applied to the ovaries for 3 hr to induce Ischemia. For the Reperfusion groups, the clamps were opened and blood flow was restored to the ovaries for 3 hr. At the end of the experiment, biochemical, histopathological, and immunohistochemical analyses were made from the tissue samples taken. Results: While MDA levels increased significantly in I and I/R groups, SOD levels decreased. It was found that ASX significantly decreased MDA levels and increased SOD activity in treatment groups depending on the dose. Caspase 3, IL-1 β , and IL-6 expressions were severely increased in Ischemia and I/R groups, while the severity of I+ASX50 and I/R+ASX100 immunoreactivity was decreased. While severe hemorrhage areas were observed in I and IR groups, minimal hemorrhage areas were observed in the treatment groups, especially in I/R+ASX100 groups. In addition, inflammatory cells and necrotic cells in the I/R group were not observed in I/R+ASX50 and I/R+ASX100 groups. Conclusion: As a result, it was determined that ASX has a strong protective role against oxidative damage in the treatment of ovarian Ischemia-Reperfusion injury.

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APA: Copy

Toktay, Erdem, Bal Tastan, Tugba, Gurbuz, Muhammet Ali, Erbas, Elif, Demir, Ozlem, & Anil Ugan, Rustem. (2022). Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 25(2), 173-178. SID. https://sid.ir/paper/989855/en

Vancouver: Copy

Toktay Erdem, Bal Tastan Tugba, Gurbuz Muhammet Ali, Erbas Elif, Demir Ozlem, Anil Ugan Rustem. Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2022;25(2):173-178. Available from: https://sid.ir/paper/989855/en

IEEE: Copy

Erdem Toktay, Tugba Bal Tastan, Muhammet Ali Gurbuz, Elif Erbas, Ozlem Demir, and Rustem Anil Ugan, “Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 25, no. 2, pp. 173–178, 2022, [Online]. Available: https://sid.ir/paper/989855/en

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