Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TATAR MUSA; Eren Ulker

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2022 | Volume:25 | Issue:2 Page(s): 214-222

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats

Author(s)

TATAR MUSA | Eren Ulker | Issue Writer Certificate

Keywords

Apoptosis

Endoplasmic reticulum-stress

Endoplasmic reticulum-chaperone BiP

Melatonin

Testis

Tunicamycin

Abstract

Objective(s): This study aimed to investigate the possible consequences of administering exogenous Melatonin as prevention or treatment against Tunicamycin-induced endoplasmic reticulum (ER) stress in the testicular tissue of rats. Materials and Methods: In this study, 42 adult Sprague Dawley rats, randomly divided into seven equal groups, were administered intraperitoneal Tunicamycin to induce ER stress. Both prophylactic (PMel) and therapeutic Melatonin (TMel) groups were administered Melatonin for seven days. ER stress in the cell was detected through immunohistochemical and molecular analyses using GPR78 expression. Results: Increased oxidant levels and Apoptosis rates were shown in testicular tissue because of ER stress. The sections in the Melatonin-administered and control groups were similar, with Melatonin-administered groups showing an increase in the antioxidant ratio. Histometric examinations revealed both TMel and Melatonin applications reduced the diameter of the tubules. However, immunohistochemical and molecular analyses showed that PMel administration decreased the concentration of GRP78 more effectively than TMel. Conclusion: Applying Melatonin prior to cell damage occurrence can be recommended for its effectiveness in protecting from Tunicamycin-induced ER stress.

Cites

No record.

References

No record.

Cite

APA: Copy

TATAR, MUSA, & Eren, Ulker. (2022). Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 25(2), 214-222. SID. https://sid.ir/paper/990640/en

Vancouver: Copy

TATAR MUSA, Eren Ulker. Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2022;25(2):214-222. Available from: https://sid.ir/paper/990640/en

IEEE: Copy

MUSA TATAR, and Ulker Eren, “Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 25, no. 2, pp. 214–222, 2022, [Online]. Available: https://sid.ir/paper/990640/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops