Comparison of anti proliferative effect of cinnamon (Cinnamomum zeylanicum) hydroalcoholic extract with cyclophosphamide medicine on A459 Cancer Cells

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Mohamadi Tayebeh; HOVEIZI ELHAM

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:167 Page(s): 21-29

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Information Journal Paper

Title

Comparison of anti proliferative effect of cinnamon (Cinnamomum zeylanicum) hydroalcoholic extract with cyclophosphamide medicine on A459 Cancer Cells

Author(s)

Mohamadi Tayebeh | HOVEIZI ELHAM | Issue Writer Certificate

Keywords

CinnamonQ2

ApoptosisQ1

A459Q1

CyclophosphamideQ2

AntioxidantQ2

Abstract

Background: Lung cancer is the most common cause of cancer death worldwide. Despite extensive efforts, an ideal medicine has not been yet found for cancer treatment. Cinnamon contains strong anti-oxidative compounds. This study evaluated and compared the lethal effect of Cinnamon extract on the A459 line lung cancer cells with Cyclophosphamide. Methods: Cinnamon extract was prepared by soxhlet set. Then A459 cells were seeded and treated with 0. 01, 0. 1, 1 and 10 mg/ml concentrations of Cinnamon and Cyclophosphamide for 1, 3 and 5 days. Cell viability and morphology were evaluated on certain days after treatment. The expression of apoptotic genes including Bad, Bax and Bcl-2 was evaluated by qRT-PCR. Results: Comparison of the cell viability percent in treated groups showed that lethal effect of Cinnamon is equal to Cyclophosphamide in 1 and 10 mg/ml concentrations on the 5th day but it was less than Cyclophosphamide in other concentrations and days (p<0. 05). Moreover, molecular findings showed that 1 and 10 mg/ml concentrations of Cinnamon extract could upregulate Bad and Bax genes expression and down regulate Bcl-2 gene expression (p<0. 05). Conclusion: Cinnamon hydroalcoholic extract can induce Apoptosis in A459 cells in a dose and time-dependent manner and be similar to Cyclophosphamide with increasing concentration.

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APA: Copy

Mohamadi, Tayebeh, & HOVEIZI, ELHAM. (2018). Comparison of anti proliferative effect of cinnamon (Cinnamomum zeylanicum) hydroalcoholic extract with cyclophosphamide medicine on A459 Cancer Cells. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(167 ), 21-29. SID. https://sid.ir/paper/9914/en

Vancouver: Copy

Mohamadi Tayebeh, HOVEIZI ELHAM. Comparison of anti proliferative effect of cinnamon (Cinnamomum zeylanicum) hydroalcoholic extract with cyclophosphamide medicine on A459 Cancer Cells. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(167 ):21-29. Available from: https://sid.ir/paper/9914/en

IEEE: Copy

Tayebeh Mohamadi, and ELHAM HOVEIZI, “Comparison of anti proliferative effect of cinnamon (Cinnamomum zeylanicum) hydroalcoholic extract with cyclophosphamide medicine on A459 Cancer Cells,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 167 , pp. 21–29, 2018, [Online]. Available: https://sid.ir/paper/9914/en

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