Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction

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Zhu Tiantian; LIU MINGHUI; Zhu Moli; LIU XU; Huang Keke; Li Wenru; Wang Shuang Xi; Yin Yaling; LI PENG

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2022 | Volume:25 | Issue:4 Page(s): 483-488

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Title

Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction

Author(s)

Keywords

Epigallocatechin-3-gallate

Insulin resistance

Insulin secretion

Pancreatic duodenal-homeobox protein-1

Type 2 diabetes mellitus

β-cell

Abstract

Objective(s): Epigallocatechin-3-gallate (EGCG) has a good therapeutic effect on Type 2 diabetes mellitus (T2DM). This work was designed to explore EGCG’ s effectiveness in Insulin resistance (IR) and pancreas islet β-cell function in a rat model of T2DM. Materials and Methods: Eight-week-old male Sprague Dawley rats were randomly divided into 6 groups, including the Control (normal diet), Diabetes (high-sucrose high-fat [HSHF] diet combined with tail vein injection of streptozotocin [STZ] for T2DM induction) and Treatment Diabetic rats which were treated with metformin [500 mg/kg/d] or EGCG [25, 50 or 100 mg/kg/d] intragastric administration for 10 weeks. With the exception of control animals, the other groups were fed the HSHF diet. EGCG’ s effects on IR and Insulin secretion were assessed by measuring body weights, and fasting blood glucose (FBG), postprandial blood glucose (PBG) and insulin levels. The morphological and molecular changes of pancreas islet β-cells were examined by hematoxylin-eosin (H&E) staining, transmission electron microscopy (TEM) and immunofluorescence. Results: Rats fed the HSHF diet combined with STZ treatment had increased body weights and blood glucose amounts, accompanied by IR and impaired β-cell function, induced T2DM, and EGCG dose-dependently restored the above indicators. Additionally, EGCG upregulated the pancreatic transcription factors pancreatic duodenal homeobox protein-1 (PDX-1) and musculoaponeurotic fibrosarcoma oncogene homolog A (MafA). Conclusion: These results suggest that EGCG reduces blood glucose amounts, and improve IR and islet β-cell disorder in T2DM.

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APA: Copy

Zhu, Tiantian, LIU, MINGHUI, Zhu, Moli, LIU, XU, Huang, Keke, Li, Wenru, Wang, Shuang Xi, & LI, PENG. (2022). Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 25(4), 483-488. SID. https://sid.ir/paper/991944/en

Vancouver: Copy

Zhu Tiantian, LIU MINGHUI, Zhu Moli, LIU XU, Huang Keke, Li Wenru, Wang Shuang Xi, LI PENG. Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2022;25(4):483-488. Available from: https://sid.ir/paper/991944/en

IEEE: Copy

Tiantian Zhu, MINGHUI LIU, Moli Zhu, XU LIU, Keke Huang, Wenru Li, Shuang Xi Wang, and PENG LI, “Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 25, no. 4, pp. 483–488, 2022, [Online]. Available: https://sid.ir/paper/991944/en

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