The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DEHBASHI MOHSEN; FATHI MEHRDAD; ATTARZADEH HOSSEINI SEYED REZA; MOSAFERI ZIAALDINI MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Internal Medicine Today Year:2021 | Volume:27 | Issue:4 Page(s): 502-517

Download Full-Text

Persian Verion

View:

154

Download:

162

Cites:

Information Journal Paper

Title

The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet

Author(s)

DEHBASHI MOHSEN | FATHI MEHRDAD | ATTARZADEH HOSSEINI SEYED REZA | MOSAFERI ZIAALDINI MOHAMMAD | Issue Writer Certificate

Keywords

Endurance training

Growth hormone

Liver

CK18

Abstract

Aims Fatty Liver and its treatment are among the concerns of today’, s society. So this study aimed to investigate the effect of Endurance training, Somatropin injection, and its lipolytic fragment (AOD9604) on cytokeratin-18 (CK18) levels and Liver enzymes of mice with fatty Liver. Methods & Materials In this experimental study, 28 male mice were randomly divided into four groups (7 mice in every group): Control (C), exercise (E), exercise + fragment (EA), and exercise + Growth hormone (EGH). A medium-intensity Endurance training program was performed for 8 weeks, 5 sessions per week with an intensity of 50% VO2max. The somatropin and fragment injection protocols were 1 mg and 250 mc/kg of body weight, respectively. The mice were evaluated 48 hours after the last training session. The obtained data were analyzed using 1-way ANOVA and post hoc Tukey tests at the significant level of P<0. 05 in SPSS version 26. Findings CK18 showed a significant decrease in group E compared to the control group only (P=0. 00). CK18 values were significantly higher in the EGH group compared to the E (P=0. 00) and EA (P=0. 04) groups. HOMA-IR (homeostatic model assessment for insulin resistance) index had a significant decrease in the E (P=0. 00) and EA (P=0. 03) groups, but no significant changes were seen in the EGH group. Changes in aspartate transaminase were not significant in any of the groups. Alanine transaminase levels in all three groups of E (P=0. 00), EGH (P=0. 03), and EA (P=0. 00) were significantly lower than those in the control group, but the inter-group changes were not significant. Conclusion Endurance training has produced a more effective response in improving nonalcoholic fatty Liver disease markers than GH and fragment peptides. Growth hormone injection can have negative consequences on some indicators of this abnormality.

Multimedia

No record.

Cites

No record.

References

Cite

APA: Copy

DEHBASHI, MOHSEN, FATHI, MEHRDAD, ATTARZADEH HOSSEINI, SEYED REZA, & MOSAFERI ZIAALDINI, MOHAMMAD. (2021). The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet. OFOGH-E-DANESH, 27(4 ), 502-517. SID. https://sid.ir/paper/992339/en

Vancouver: Copy

DEHBASHI MOHSEN, FATHI MEHRDAD, ATTARZADEH HOSSEINI SEYED REZA, MOSAFERI ZIAALDINI MOHAMMAD. The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet. OFOGH-E-DANESH[Internet]. 2021;27(4 ):502-517. Available from: https://sid.ir/paper/992339/en

IEEE: Copy

MOHSEN DEHBASHI, MEHRDAD FATHI, SEYED REZA ATTARZADEH HOSSEINI, and MOHAMMAD MOSAFERI ZIAALDINI, “The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet,” OFOGH-E-DANESH, vol. 27, no. 4 , pp. 502–517, 2021, [Online]. Available: https://sid.ir/paper/992339/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops