Effect of Insulin Resistance on Colorectal Cancer: The Role of Plasma Adiponectin Level

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VAHEDIAN MOSTAFA; Eshagh Hoseini Seyed Jalal; HAMTA AMIR; SAADATI MOHAMMADREZA; FARAHANI HAMID

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Journal: Iranian Red Crescent Medical Journal Year:2022 | Volume:24 | Issue:4 Page(s): 0-0

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Title

Effect of Insulin Resistance on Colorectal Cancer: The Role of Plasma Adiponectin Level

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Keywords

Adiponectin

Colorectal cancer

Insulin resistance

Obesity

Abstract

Background: Despite clinical and different basic investigations, the role of plasma adipokines, such as Adiponectin as a precise predictor of the risk of Colorectal cancer (CRC) is still conflicting. Objectives: This study investigated the association between CRC and Insulin resistance, Obesity, and plasma Adiponectin level for the first time in Iran. Methods: A total of 80 subjects (including 45 CRC patients and 35 healthy individuals) were enrolled in this case-control study. Demographic, anthropometric, and clinical data were recorded, and serum levels of Adiponectin, insulin, and glucose were evaluated using enzyme-linked immunosorbent assay and glucose oxidase technique, respectively. Insulin resistance index (HOMA-IR) was measured as well. Results: The mean±, SD plasma Adiponectin concentration in the CRC patients (7. 98±, 0. 64 ng/ml) was not significantly higher, than the control group (8. 05±, 1. 14 ng/mL). However, the mean±, SD of HOMA-IR and plasma glucose levels (1. 81±, 0. 61 and 7. 64±, 1. 34 mm/L, respectively) of the CRC group were significantly higher (P<0. 05), compared to the control group (1. 37±, 0. 3 and 119±, 1. 1 mg/dL, respectively),though, plasma insulin wasn’, t significantly different in the two study groups. Following the stratification of CRC patients according to the tumor site, a significantly lower level of Adiponectin (7. 36 ±, 1. 1 ng/ml) (P<0. 05) and a significantly higher level of HOMAIR (2. 08±, 0. 44) were observed in patients with colon cancer (P<0. 005), compared to the controls. Regression among the plasma Adiponectin and the plasma insulin and HOMA-IR was negative in the control and CRC groups. Conclusion: Insulin resistance has an important role in the development of CRC, especially in the genesis colon cancer, regardless of the change it causes in plasma levels of Adiponectin.

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APA: Copy

VAHEDIAN, MOSTAFA, Eshagh Hoseini, Seyed Jalal, HAMTA, AMIR, SAADATI, MOHAMMADREZA, & FARAHANI, HAMID. (2022). Effect of Insulin Resistance on Colorectal Cancer: The Role of Plasma Adiponectin Level. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 24(4), 0-0. SID. https://sid.ir/paper/993531/en

Vancouver: Copy

VAHEDIAN MOSTAFA, Eshagh Hoseini Seyed Jalal, HAMTA AMIR, SAADATI MOHAMMADREZA, FARAHANI HAMID. Effect of Insulin Resistance on Colorectal Cancer: The Role of Plasma Adiponectin Level. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2022;24(4):0-0. Available from: https://sid.ir/paper/993531/en

IEEE: Copy

MOSTAFA VAHEDIAN, Seyed Jalal Eshagh Hoseini, AMIR HAMTA, MOHAMMADREZA SAADATI, and HAMID FARAHANI, “Effect of Insulin Resistance on Colorectal Cancer: The Role of Plasma Adiponectin Level,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 24, no. 4, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/993531/en

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