Determination of Oseltamivir Resistance Level by an H275Y Genotyping Assay among Influenza A (H1N1) Viruses in Hamadan Province, Iran

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mahmoudvand Shahab; AMINI RAZIEH; AZIZI JALILIAN FARID; HEDAYAT YAGHOOBI MOJTABA; javaheri Masoumeh; SEDIGHI IRAJ; MAMANI MOJGAN; Ezati Razieh; Amiri Jalaleddin; Saeedi Jam Masoud

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2022 | Volume:30 | Issue:3 Page(s): 55-61

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Determination of Oseltamivir Resistance Level by an H275Y Genotyping Assay among Influenza A (H1N1) Viruses in Hamadan Province, Iran

Author(s)

Keywords

Drug resistance

Influenza A (H1N1) virus

Oseltamivir

Abstract

Introduction: Epidemics and deaths caused by influenza viruses are an important concern worldwide. The use of neuraminidase inhibitors such as Oseltamivir is an effective and valuable way to treat the diseases caused by these viruses. However, the mutation in several parts of the gene leads to the emergence of drug-resistant strains, and an ever-increasing rise in drug-resistant strains is a global problem. Histidine-to-tyrosine mutation at position 275 (H275Y) of neuraminidase protein is one of the most common Oseltamivir resistance mutations. This study aimed to detect H275Y mutation in influenza A (H1N1) virus circulating in the Hamadan province of Iran using real-time polymerase chain reaction (RT-PCR). Material & Methods: This cross-sectional study was conducted on 110 swab samples isolated from patients with suspected influenza virus infection between 2015 and 2016. Ribonucleic acid (RNA) was extracted from samples and the RTPCR method was used to determine virus types and subtypes. The positive samples were evaluated for detection of H275Y mutation using RT-PCR. (Ethic code: IR. UMSHA. REC. 1400. 917) Findings: Out of 110 patients in this study, 50 (45%) were females and 60 (55%) were males. The mean±, SD age of participants was 40. 74±, 2. 42 years. Influenza A (H1N1) virus was found in 22 (20%) out of 110 patients, including 9/50 (18%) females and 13/60 (21. 7%) males. There was no significant relationship between the virus and gender (P=0. 81). No Drug resistance related to H275Y mutation was observed in 22 positive cases. Discussion & Conclusion: The findings indicated that no Drug resistance mutations have occurred, and Oseltamivir is still an appropriate option to treat infections caused by the influenza virus in Hamadan province, Iran. However, due to the increasing number of resistant strains, an annual review of Oseltamivir resistance is recommended and further studies are needed in this regard.

Cites

No record.

References

No record.

Cite

APA: Copy

Mahmoudvand, Shahab, AMINI, RAZIEH, AZIZI JALILIAN, FARID, HEDAYAT YAGHOOBI, MOJTABA, javaheri, Masoumeh, SEDIGHI, IRAJ, MAMANI, MOJGAN, Ezati, Razieh, Amiri, Jalaleddin, & Saeedi Jam, Masoud. (2022). Determination of Oseltamivir Resistance Level by an H275Y Genotyping Assay among Influenza A (H1N1) Viruses in Hamadan Province, Iran. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 30(3 ), 55-61. SID. https://sid.ir/paper/999925/en

Vancouver: Copy

Mahmoudvand Shahab, AMINI RAZIEH, AZIZI JALILIAN FARID, HEDAYAT YAGHOOBI MOJTABA, javaheri Masoumeh, SEDIGHI IRAJ, MAMANI MOJGAN, Ezati Razieh, Amiri Jalaleddin, Saeedi Jam Masoud. Determination of Oseltamivir Resistance Level by an H275Y Genotyping Assay among Influenza A (H1N1) Viruses in Hamadan Province, Iran. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;30(3 ):55-61. Available from: https://sid.ir/paper/999925/en

IEEE: Copy

Shahab Mahmoudvand, RAZIEH AMINI, FARID AZIZI JALILIAN, MOJTABA HEDAYAT YAGHOOBI, Masoumeh javaheri, IRAJ SEDIGHI, MOJGAN MAMANI, Razieh Ezati, Jalaleddin Amiri, and Masoud Saeedi Jam, “Determination of Oseltamivir Resistance Level by an H275Y Genotyping Assay among Influenza A (H1N1) Viruses in Hamadan Province, Iran,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 3 , pp. 55–61, 2022, [Online]. Available: https://sid.ir/paper/999925/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops