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Title

Effect of moderate-intensity continuous training and high-intensity interval training with astaxanthin supplementation on inflammatory factors of cardiac tissue in type 2 diabetic rats

Pages

  12-22

Abstract

 Background and aims: The prevalence of diabetes has made necessary changes in lifestyle to prevent its complications. In this study, the effect of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) with staxanthin supplementation on inflammatory biomarkers in the cardiac tissue of diabetic Rats was investigated. Methods: In this study, 42 male Rats (age six weeks), after induction of Type 2 Diabetes, were randomly divided into seven groups (six in each group): 1)diabetic control; 2) diabetic Sham; 3) diabetes+supplement; 4) diabetes+HIIT; 5) diabetes+HIIT+supplement; 6) diabetes+MICT; and 7) diabetes+MICT+supplement. The HIIT groups ran with an intensity of 80% VO2max, and MICT groups ran with an intensity of about 65% to 75% VO2max on the treadmill (five sessions per week for eight weeks). The supplement was taken daily at a dose of 3 mg per kg. The cardiac tissue was removed 24h after the last training session (night fasting). Inflammatory biomarkers (IL-1b, IL-6, TNF-α , and CRP) of the cardiac tissue were measured by Western blotting. Results: After eight weeks of training, inflammatory biomarkers showed a significant decrease compared to the control group (p<0. 05), and no significant changes were observed in the supplement group. Conclusion: Due to the effect of MICT and HIIT in reducing inflammatory biomarkers, it can be used as a therapeutic strategy. It seems that the MICT with supplements may have more effective in these patients, while supplements alone have no effect on inflammatory markers.

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    APA: Copy

    Azizzadeh, Tohid, ZOLFAGHARI, MOHAMMAD REZA, FATTAHI, AMIR, & KHADEM VATANI, KAMAL. (2021). Effect of moderate-intensity continuous training and high-intensity interval training with astaxanthin supplementation on inflammatory factors of cardiac tissue in type 2 diabetic rats. EBNESINA, 23(3 (76) ), 12-22. SID. https://sid.ir/paper/954068/en

    Vancouver: Copy

    Azizzadeh Tohid, ZOLFAGHARI MOHAMMAD REZA, FATTAHI AMIR, KHADEM VATANI KAMAL. Effect of moderate-intensity continuous training and high-intensity interval training with astaxanthin supplementation on inflammatory factors of cardiac tissue in type 2 diabetic rats. EBNESINA[Internet]. 2021;23(3 (76) ):12-22. Available from: https://sid.ir/paper/954068/en

    IEEE: Copy

    Tohid Azizzadeh, MOHAMMAD REZA ZOLFAGHARI, AMIR FATTAHI, and KAMAL KHADEM VATANI, “Effect of moderate-intensity continuous training and high-intensity interval training with astaxanthin supplementation on inflammatory factors of cardiac tissue in type 2 diabetic rats,” EBNESINA, vol. 23, no. 3 (76) , pp. 12–22, 2021, [Online]. Available: https://sid.ir/paper/954068/en

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