Journal of Birjand University of Medical Sciences
Year:2018 | Volume:25 | Issue:3 |Papers Count:11

Background and Aim: Helicobacter Pylori is one of the human gastrointestinal tract bacteria that affects more than 50% of the world's population. Eradication of Helicobacter with an effective regimen with low cost and minor side effects is very worthwhile. The aim of this study is to evaluate the rate of Helicobacter Pylori eradication by adding green tea extract to the common 3 drugs regimen consist of amoxicillin, clarithromycin, and pantoprazole in Birjand. Materials and Methods: In this randomized controlled clinical trial study, 30 patients in the case group and 30 Persons in the control group were enrolled. Diagnosis in patients with dyspepsia was performed based on endoscopy or urea breath test according to the clinical setting. The case group was treated with the common 3-drug regimen and green tea extract, and the control group was treated with common 3-drug regimen alone for 14 days. Eight weeks after treatment for Helicobacter Pylori eradication, urea breath test results were compared in two groups. Results: The rate of eradication of Helicobacter pylori infection in the addition of green tea to 3 drug regimen based on clarithromycin (experimental group) was 90%, which was 13. 7% more than the control group. The rate of eradication in the control group was 76. 7%. There was no significant difference between the two groups in terms of side effects in both experimental and control groups. Conclusion: Although the difference in the degree of eradication in the two groups was not statistically significant, But given the importance of increasing eradication at the limit Add side effects such as bismuth with metronidazole without adding complications And having other beneficial effects of green tea, These results are clinically valuable. According to the results of this study, green tea can be added as a useful supplement in the treatment of Helicobacter Pylori infection along with the common 3 drug regimen.

Background and Aim: The obsessive-compulsive disorder is one of the major problems in mental health. Growth experiences such as attachment play an important role in the formation of mental harm. This research has been designed with the aim of investigating schema therapy on attachment styles (secure, insecure anxiety& insecure avoidance) and symptoms of patients with obsessive-compulsive disorder. Materials and Methods: In this clinical trial study, the statistical population of the patients referring to Birjand psychiatric clinic was that based on entry criteria, thirty-two persons were randomly assigned with a replacement entered studying. The data collection tool was Yale-Brown obsessive and the Hazen and Shaver attachment style questionnaire. The collected data were analyzed by SPSS software (Version 22) by independent t-test, repeated measures ANOVA and Post-Hoc Bonferroni, at a significant level (P <0. 05). Results: The mean scores of post-test and fallow up in three attachment styles and obsessive scores in the experimental group had a significant difference with the control group (P<0. 001). In the schema group, the mean score of the two insecure attachment styles (secure, insecure anxiety& insecure avoidance) (avoidance and anxiety) and obsessive-compulsive symptoms in the post-test had a significant decrease with the score of pre-test and the scores of secure attachment style showed a significant increase (P<0. 001). Conclusion: According to the results, attachment styles especially insecure anxiety and insecure avoidance attachment styles are associated with obsessive-compulsive symptoms and schema therapy through the effect of adjusted attachment styles can reduce the symptoms of obsessive-compulsive disorder.

Background and Aim: Aloe Vera gel, with strong antioxidant properties, is used in the treatment of many renal disorders. This study aimed to evaluate the effect of Aloe Vera gel (JA) on urea, uric acid and creatinine levels of serum, and tissue structure of kidneys of rats diagnosed with MS through Ethidium Bromide (EB). Materials and Methods: This experimental study was performed on 48 female rats, which were divided into 6 groups of 8 samples, including control, sham (intraventricular treatment with saline), experimental treated with 14? l of EB solution to the lateral ventricles with normal saline as a Gavage and receivers of 300, 600 and 1200 mg/ kg alcoholic extracts (JA), as gavage with EB intraventricular meditation. In this study, prescriptions were taken for 35 days. In the end, after blood sampling from animal’ s heart, some amount of urea, uric acid, and creatinine are extracted, and with providing different cross-sections, the tissue structure of their kidneys was studied based on histologic measurements. Finally, the data were analyzed using SPSS software (Version 20) using ANOVA and Duncan tests at the level of P <0. 05. Results: The results showed that EB increased serum urea, uric acid, and creatinine levels, decreased the diameter of the medulla, glomerulus, renal corpuscle sections, and increased the diameter of the near and further curved tubes at the level of P≤ 0. 05. Furthermore, the treatment with high-dose JA significantly reduced the serum urea, uric acid and creatinine levels, increased the diameter of medulla sections, glomerulus, renal corpuscle, and reduced the near and further curved tubes alone in comparison with the EB group at P≤ 0. 05. Conclusion: Aloe Vera gel, in dose-dependent forms, can reduce urea, uric acid, creatinine, and tissue modification of kidneys in animals with MS.

Background and Aim: Phenolic compounds form an important category of antioxidants that have important biological activities, such as anticancer, antifungal, antibacterial and antiviral effects. In this study, the anticancer effects of Gallic acid and P-Coumaric acid were studied on MDA-MB-231 human breast cancer cell line. Materials and Methods: In this experimental study, human breast cancer cells of MDA-MB-231 (104 cells) were treated with Gallic acid, P-Coumaric Acid in different concentrations (0, 10, 25, 50 and 100? g / ml) for 24 hours. The cell viability of treated cells was determined using MTT assay and invert light microscopy. Results: The cell viability of treated cell with 100? g/ml Gallic cell is about 16%, and in the case of paracoumaric acid at the similar concentration, the cell viability is about 83%. The morphological study confirmed the results of MTT using an inverted light microscope. Conclusion: The inhibitory effect of Gallic acid in MDA-MB-231 human breast cancer cells is higher in comparison to P-Coumaric acid at the similar concentration. According to the study, this effect could be due to the difference in the number of hydroxyl groups on these compounds.

Background and Aim: Premenstrual syndrome is one of the most common disorders of reproductive age, which has significant effects on women's economic, social and professional status. The aim of this study was to determine the effect of Iron and vitamin D supplementation on the severity of premenstrual syndrome symptoms through High school Students in the City of Birjand in 2015-2016. Materials and Methods: This quasi-experimental study was performed on 149 students in the grade of Junior high school and senior high school which were selected by random sampling. The participants completed the standard questionnaire for the screening of premenstrual symptoms in order to measure the mood, physical symptoms and effects of these symptoms in the three stages before and after 16 weeks of iron and 9 months of vitamin D supplementation. Data were analyzed by SPSS software (version 16) using Chi-square test, repeat ANOVA, one-way ANOVA and Friedman nonparametric test were analyzed at a significant level less than 0. 05. Results: There were 56 students (37. 6%) in the PMS group, 19 (12. 8%) in the PMDD group and 74 (49. 7%) in the non-affected group. The comparison of scores in three study periods showed that the severity of affective symptoms (p=0. 005) and effects of the symptoms (p=0. 015) in the PMDD group, and only the effects of symptoms (p=0. 011) in the PMS group, were reduced, But there was no change in the scores of somatic symptoms in these two groups. In non-affected group, the scores of these three areas showed a significant increase. Conclusion: The Iron and vitamin D supplementation may reduce symptoms of premenstrual syndrome. Further studies are recommended in this area.

Background and Aim: The antioxidant supplements to reduce the damaging effects of free radicals after extreme sports is crucial; Thus, the effect of Jujube fruit consumption on serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α ) young men after an intensive anaerobic exercise is studied. Materials and Methods: The present study was a control quasi-experimental research with two-group including exercise with and without jujube fruit juice. 20 young males were randomly assigned into two homogeneous groups including exercise and user jujube fruit (0. 4 mg/kg for 3 weeks) and exercise group. Both groups participated in 30-second Wingate test. Blood samples were collected at three stages including the base, after jujube fruit consumption and after the exercise protocol. Results in SPSS software (version 15) with independent t-tests, analysis of variance with repeated measurements and Post-Hoc Bonferroni, at a significant level, p≤ 0. 05 was extracted. Results: The baseline IL-6 was significantly lower than before and after the Wingate test (p<0. 05) and in the training group, IL-6 was significantly higher after the Wingate test than the baseline (p=0. 01). The TNF-α post-Wingate test was significantly higher than the baseline and before the test (p<0. 05). In the training group, the TNF-α was not statistically significant (p=0. 06) in three phases. Moreover, there were no significant differences between the IL-6 and TNF-α changes in the post and or pre-test with the baseline in both experimental or control groups (p>0. 05). Conclusion: Jujube fruits do not have the potential to control the IL-6 and TNF-α as inflammatory markers following of the intensive anaerobic workouts.

Background and Aim: Diabetes is one of the most common chronic metabolic diseases. If there is no action to prevent, control and treat it, there will be many problems for the community. The aim of this study was to evaluate the knowledge, attitude, and performance of high school girl students of the second period in Birjand regarding diabetes and its related factors. Materials and Methods: This Cross-Sectional analytical study examined 362 high school girl students of the second period in Birjand in 2016-2017. The sampling method was multi-stage clustering. Data collection was done by a self-made questionnaire which confirmed its content validity by 7 faculty members of the university. To verify the reliability of the questionnaire, Cronbach's alpha coefficient was 0. 78 for questions, 0. 64 for attitude questions and 0. 67 for performance questions. Finally, the data were analyzed by SPSS (Version 19) software, independent t test, one-way ANOVA and Tukey's post hoc test at a significant level of α = 0. 05. Results: The mean score of students' knowledge was 5. 2 ± 1. 27 at a poor level, the mean score of attitude was 21. 9 ± 10. 9 ± 9. 9 and at the mean level and the mean performance score was 14. 8 ± 8. 8 and was on moderate. Also, Knowledge and attitude score in experimental students was significantly higher than those in mathematics and technology (P <0. 001). Conclusion: Knowledge score in students about diabetes and its related factors is poor and their attitude and performance at the moderate level. Since there is a direct relationship between the individual's knowledge of one issue and his vision and performance, the organization of health education sessions in this regard and the addition of information to textbooks are needed to improve and raise awareness and prevent diabetes.

Background and Aim: Risk of mortality associated with nosocomial infections in health centers as a problem has always existed. These infections can be transmitted through contact with the environment or equipment to patients. Therefore, the present study was conducted with the aim of evaluating the frequency of bacterial contamination in different parts of the center Educational and therapeutic center in Qaen Shohada Hospital during the years 2011-2016. Materials and Methods: In this retrospective descriptive study, Data are collected through archived information in the Infection Control Department of the Educational and Therapeutic Center in Qaen shohada Hospital during the years 2011-2016 The sampling was done by the census. Variables such as year, physical environment, sampling levels, equipment, type of bacteria (gram positive or negative) were recorded in the checklist. Type of bacteria based on blood agar and EMB agar and gram stain was performed. Finally, the data were analyzed by SPSS software (version 20) and analyzed using Chi-Square tests and Fisher exact test. Results: The results of this study showed that of 1758 samples, 542 cases (30. 8%) had bacterial contamination. The most bacterial strains were gram-positive (77. 3%). Among the different parts of the hospital, the highest contamination was found in the kitchen (75%) and then the internal section (51. 3%). Among the equipment that was cultured on the bacteria, the most contamination was related to medical equipment (69. 3%). Conclusion: The study showed that bacterial contamination levels and departments of different hospitals are significant. The use of standard preventive and controlling infectious disease guidelines can be effective in reducing these infections.

Background and Aim: Among the medical wastes, dental wastes have a high diversity and due to its high contents of hazardous, toxic, and pathogenic agents, therefore these wastes are of great importance. The aim of this study was to investigate and analyze the amount of waste produced in dentistry offices in Birjand. Materials and Methods: In this descriptive cross-sectional study, 48 dental offices in the city of Birjand were studied. Sampling was carried out by environmental health experts in three consecutive working days (Monday, Tuesday, and Wednesday) from every center. The Samples were divided into 5 categories such as semi-domestic, infectious, chemical-pharmaceutical, toxic and sharp material, Separated and weighed using a laboratory scale. Information was expressed as percentage by weight. Results: Based on the results, the total amount of waste produced in dental offices in Birjand was 7848. 02 kg / year. percentages of semi-domestic, infectious, chemical-pharmaceutical, sharp material, and toxic wastes were 54. 3%, 29. 7%, 11. 8%, 3. 9% and 0. 11% respectively. Conclusion: Considering the high volume of dental waste, especially infectious and hazardous materials, the need for separation and recycling in the office is evident. It is necessary to manage the wastes and their separation and recycling in source place.