Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide

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Tanomand Sedigheh; HOSSEINI SEYED EBRAHIM; Edalatmanesh Mohamad Amin

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Journal: Journal of Birjand University of Medical Sciences Year:2018 | Volume:25 | Issue:3 Page(s): 193-202

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Title

Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide

Author(s)

Tanomand Sedigheh | HOSSEINI SEYED EBRAHIM | Edalatmanesh Mohamad Amin | Issue Writer Certificate

Keywords

UreaQ2

Uric AcidQ2

CreatinineQ2

Multiple SclerosisQ2

Aloe VeraQ2

Abstract

Background and Aim: Aloe Vera gel, with strong antioxidant properties, is used in the treatment of many renal disorders. This study aimed to evaluate the effect of Aloe Vera gel (JA) on Urea, Uric Acid and Creatinine levels of serum, and tissue structure of kidneys of rats diagnosed with MS through Ethidium Bromide (EB). Materials and Methods: This experimental study was performed on 48 female rats, which were divided into 6 groups of 8 samples, including control, sham (intraventricular treatment with saline), experimental treated with 14? l of EB solution to the lateral ventricles with normal saline as a Gavage and receivers of 300, 600 and 1200 mg/ kg alcoholic extracts (JA), as gavage with EB intraventricular meditation. In this study, prescriptions were taken for 35 days. In the end, after blood sampling from animal’ s heart, some amount of Urea, Uric Acid, and Creatinine are extracted, and with providing different cross-sections, the tissue structure of their kidneys was studied based on histologic measurements. Finally, the data were analyzed using SPSS software (Version 20) using ANOVA and Duncan tests at the level of P <0. 05. Results: The results showed that EB increased serum Urea, Uric Acid, and Creatinine levels, decreased the diameter of the medulla, glomerulus, renal corpuscle sections, and increased the diameter of the near and further curved tubes at the level of P≤ 0. 05. Furthermore, the treatment with high-dose JA significantly reduced the serum Urea, Uric Acid and Creatinine levels, increased the diameter of medulla sections, glomerulus, renal corpuscle, and reduced the near and further curved tubes alone in comparison with the EB group at P≤ 0. 05. Conclusion: Aloe Vera gel, in dose-dependent forms, can reduce Urea, Uric Acid, Creatinine, and tissue modification of kidneys in animals with MS.

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APA: Copy

Tanomand, Sedigheh, HOSSEINI, SEYED EBRAHIM, & Edalatmanesh, Mohamad Amin. (2018). Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 25(3 ), 193-202. SID. https://sid.ir/paper/95542/en

Vancouver: Copy

Tanomand Sedigheh, HOSSEINI SEYED EBRAHIM, Edalatmanesh Mohamad Amin. Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(3 ):193-202. Available from: https://sid.ir/paper/95542/en

IEEE: Copy

Sedigheh Tanomand, SEYED EBRAHIM HOSSEINI, and Mohamad Amin Edalatmanesh, “Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3 , pp. 193–202, 2018, [Online]. Available: https://sid.ir/paper/95542/en

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