Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells

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Khorsandi Khatereh; Hosseinzadeh Reza; Khatibi Shahidi Fedora; Chamani Elham

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Journal: Journal of Birjand University of Medical Sciences Year:2018 | Volume:25 | Issue:3 Page(s): 203-212

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Information Journal Paper

Title

Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells

Author(s)

Khorsandi Khatereh | Hosseinzadeh Reza | Khatibi Shahidi Fedora | Chamani Elham | Issue Writer Certificate

Keywords

Phenolic CompoundsQ2

Gallic AcidQ1

Para-Coumaric AcidQ1

Human Breast Cancer CellsQ1

Cell ViabilityQ1

Abstract

Background and Aim: Phenolic Compounds form an important category of antioxidants that have important biological activities, such as anticancer, antifungal, antibacterial and antiviral effects. In this study, the anticancer effects of Gallic Acid and P-Coumaric acid were studied on MDA-MB-231 human breast cancer cell line. Materials and Methods: In this experimental study, Human Breast Cancer Cells of MDA-MB-231 (104 cells) were treated with Gallic Acid, P-Coumaric Acid in different concentrations (0, 10, 25, 50 and 100? g / ml) for 24 hours. The Cell Viability of treated cells was determined using MTT assay and invert light microscopy. Results: The Cell Viability of treated cell with 100? g/ml Gallic cell is about 16%, and in the case of paracoumaric acid at the similar concentration, the Cell Viability is about 83%. The morphological study confirmed the results of MTT using an inverted light microscope. Conclusion: The inhibitory effect of Gallic Acid in MDA-MB-231 Human Breast Cancer Cells is higher in comparison to P-Coumaric acid at the similar concentration. According to the study, this effect could be due to the difference in the number of hydroxyl groups on these compounds.

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APA: Copy

Khorsandi, Khatereh, Hosseinzadeh, Reza, Khatibi Shahidi, Fedora, & Chamani, Elham. (2018). Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 25(3 ), 203-212. SID. https://sid.ir/paper/95540/en

Vancouver: Copy

Khorsandi Khatereh, Hosseinzadeh Reza, Khatibi Shahidi Fedora, Chamani Elham. Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(3 ):203-212. Available from: https://sid.ir/paper/95540/en

IEEE: Copy

Khatereh Khorsandi, Reza Hosseinzadeh, Fedora Khatibi Shahidi, and Elham Chamani, “Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3 , pp. 203–212, 2018, [Online]. Available: https://sid.ir/paper/95540/en

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