This research explored the relationship between mental health (somatic symptoms, anxiety, insomnia, depression and social dysfunctioning), coping styles, religious attitudes and life satisfaction. A random selection of 120 (55 males, mean age: 30 and 65 females, mean age: 27) Isfahan people answered the General Health Questionnaire (Goldberg & Hillier, 1979), The Coping Inventory for Stressful Situations (Parker & Endler, 1990), Religious Attitudes Questionnaire (Keshavarz, Mehrabi & Soltanizadeh, 2009) and the Satisfaction with Life Scale (Diener, Emmons, Larsen, & Griffin, 1985). Results showed life satisfaction was correlated: a) negatively with somatic symptoms, insomnia and emotion-focused coping style; b) positively with a belief in principles of religion, performing religious rituals, reverence, and problem-focused coping style. Step by step regression analysis revealed that 45% of life satisfaction could be explained by symptoms of depression (25%), reverence (8%), emotion-focused coping (7%), avoidant coping (3%), and social dysfunctioning (2%). The roles of mental health, coping styles, and religious attitudes in life satisfaction are discussed.