Jundishapur Scientific Medical Journal
Year:2002 | Volume:- | Issue:34|Papers Count:12

Diabetic nephropathy is the most common cause of end stage renal disease (ESRD) in many countries . Heamodialysis and transplantation are two modality of treatments and these patients can take advantage of them.Primary results of transplatation in this patients were very poor , but patient and transplanted kidney survival had gradually increased .This study was about kidney transplantation results in diabetics , in Golestan hospital in Ahwaz. All transplantations in the period between 1370 to 1378 were considered and patients were divided in two diabetic, and non diabetic groups.Twenty diabetics consisted of 19 males and one female , with the avarage age of 49 years. 198 non diabetics consisted of 138 males and 60 females were studied. Lout of 20 diabetic patients, were expired after two years , one of them 7 days after transplantation due to septicemia and, the other 4 months after transplantation due. to MI. So the diabetic transplanted patients survival was 90% . in 198 non diabetics , one year survival was 94% . Two year survival of diabetics and non diabetics was 90% and 89% respectively. 18 diabetic patients lived one year after transplantation , one is still under hemodialysis functional transplantation. 23 out of 198 non diabetic patients, expired due to septicema, pneumonia , and cardiovascular diseases . 7 patients returned to haemodialysis . One year survival of diabetic graft was 85% , but 89% in non diabetics . Two year survival of graft in diabetics and non diabetics was 85% a86% respectively

Haemoglobin (Hb) H is moderately severe disease resembles thalassemia intermedia with mild splenomegaly. Because Hb H is unstable and precipitate within the red cell, hemolysis occurs. This is a report of 4 cases of Hb H disease. Hb H was demonstrated by incubation of blood with supravital oxidizing stains such as %1 brilliant cresule blue.Hb electerophorisis of freshly prepared hemolysate at alkaline PH demosterated a fast moving component amounting 5-30 of total Hb. CBC showed low Hb, Low MCV, Low MCH, Low MCHC, and high RDW, Normal to high RBC count. The typical patients were generaley anemic with Hb of 8-10 g/dl, one patients had Hb level as Low as 5.5 g/dl (case 3), the complication of Hb H disease were those related to chronic hemolysis, jaundice, hepato spleenomegaly, folate deficiency, and suseptibility to infection (case 4). Hemolytic episodes is probably precipitated by drugs or infection (case 3,4).Hb H disease consistent with beningn course. Growth, maturation, marriage, pregnancy, empolyment, are with in normal limits. Therapy inculudes supplementation with folic acid, avoidence of oxidant drugs prompt treatment of infection episodes by antibiotics, and in case of anemia use transfiusion as paliative treatment.

Liver has an important role in lipid metabolism and vitamin A storage. This study was done to determine the effects of fatty diet consumption during pregnancy on the F.S.C and vitamin A status in newborn rabbits liver. In this study 15 rabbits were divided into 3 groups, each one contained 1 male and 4 females. After pregnancy, the pregnant rabbits divided to 3 Groups; 1: ordinary diet, 2: diet containing 10% (Fish oil) and 3: diet containing 10% (corn oil). When the newborns became 8 weeks old, all of the animals were killed, the liver autopsies obtained, mother samples prepared for H&E staining and L.M studies, but newborn for H&E and metylen blue staining and L.M & T.E.M studies. We found lipid degeneration and fibrosis in the livers of mothers, but no changes in newborns with L.M study.E.M studies of newborn liver have shown increases in (F.S.C) that comes from fibroblast differentiation, and accumulation of fatty droplets within their cytoplasms.According to these findings we conclude that these changes are due to the consumption of fatty diets, which contain lipids, inspite of the verity of those lipids. According to other papers we suggest that this fatty accumulation in the F.S.C will be followed by vitamin A sterification, so vitamin A will decrease in the liver.

Cytokines are secreted as the molecular products of different cells in particular T - lymphocyte which contribute in the processes of immune response. Brucellosis is caused by intracellular bacteria and as such the cell-mediated immunity (C.M.I) plays a crucial role in immune responses during the course of infection. Thus a study on cytokine production among patients with brucellosis may provide valuable information regarding the function of C.M.I in this disease.71 patients with acute brucellosis and 12 normal apparanth healthy medical students and blood donors took part in this investigation. Diagnosis of the disease was based on case history, clinical examination and serological tests. The levels of IL-12, IL-2, IFN- ,g IL-4 and IL-10 in serum were measured by ELISA. The results indicated that the levels of IL - 2, and IL - 4 in the sera of patients had increased slightly. Among all cytokines, mean IFN-g level showed the highest increase in patients. The levels of IL- 12 and IL - 10 in the sera of patients did not show any appreciable difference with those of normal controls. These results indicated a Th1 type of immune response in patients with acute brucellosis.

The main objective of this research was to determine the effects of soy isoflavones on serum lipids, lipoproteins and fasting blood sugar levels in hypercholesterolemic rabbits. Twenty four male New Zealand rabbits received basic pellete diet for two weeks and then were placed on hypercholesterolemic diets (pelletes plus 1% cholesterol) for three weeks. After elevation of total and LDL-cholesterol (about ten folds), groups 1-3 received 100g soy protein containing 200gr (ISO++), 100mg (ISO+) and soy protein diet without isoflavones (ISO-), for six weeks, respectively, and group 4 kept on hypercholesterolemic diet (CHO).Results showed no change in total and LDL-cholesterol levels with ISO++ diet, but two folds increases with ISO+ and ISO- in comparison with baseline and CHO diets (P<0.000). HDL-cholesterol significantly increased after ingestion of CHO diet and remained elevated (almost three folds) by the soy diets. Triglycerides and VLDL-cholesterol increased by all soy diets but only in ISO+ and ISO- diets were significantly higher than baseline (P<0.05).Fasting blood sugar levels were not changed by the soy diets. These results suggest that soy isoflavones have ameliorated the lipid profile but have not changed blood sugar levels so can exert clinical improvement in hyperlipidemias specially when cholesterol intake is simultaneously decreases.

Rosmarinus officinalis L. (Rosemary) is one of the important medicinal plants of Lamiaceae family cultived in Iran. In this research, the aerial parts of rosemary were investigated for identification of flavonoids and essential oil components.The isolation of flavonoids was carried out by means of preparative thin layer chromatography of hydro- methanolic extracts of the plant. Two flavones or flavonols (possibly dihydroflavonols) were obtained. The structures of the flavonoids were determined by methods based on UV spectroscopy. The essential oil was analyzed by GC-MS and thin layer chromatography. The identification of the essential oil components was based on GC retention indices relative to n-alkanes and comparing their retention times, mass spectra and fragmentation patterns with corresponding literature data. The main components of the rosemary oil were : tricyclene, 1,8-cineole, camphor, camphene and bornyl acetate.

Sacrococcygeal tratoma (SCT) is the most common benign congenital tumor with suscebtibility to neoplasm of the fetus. This tumor contains derivatives of more than one of the three embryonic- germ cell layers and usually arises as a mass in the sacrococcygeal region.Management of anesthesia for these group of patients have many problems. The neonate has unique requirements for equipments, interavenus access, airway management, fluid and drugtherapy, anesthetic dosage and environmental control. This neonatal procedure is too numerous to describe that includes positioning during intubation (lateral decubitus) and surgery (prone position) and thus adequacy of patency airway to become difficult. Critical fluid and bloodthrapy, unknown congenital malformations e.g cardiac malformation and finally every effort must be made to maintain the infants temprature to minimize termal stress and hypotemia. This report demonstrates a 6 days old neonate with SCT type 1. The tumor mass was 2000 grams. Because of large tumor mass, the neonate was intubated in lateral decubitus position and was put to prone position for operation. then the presetation of this patient will discussed management of anesthesia.

This research shows that the antimicrobial property of Lactobacillus Bulgaricus is mainly due to its bacteriocin. Since using bacteriocin treat some diseases, has been studied considerably and some desirable gains have been obtained, in this study it has been tried to assess the effect of supernatant of L.Bulgaricus culture containiny bacteriocin upon the sensitivity of Listeria onocytoges to the antibiotic.In this experiment the cell-free liquid was first made through the Lactobacillus culture, then it was neutralized by Millipor Filter and it was added by the ratio 2.5%,5%.7.5% and 10% to the pure strains of Listeria culture media and the sensitivity test was done by disk method. 14 antibiotic disks were used and only positive reaction in Tetracylin were seen.

Acute Rheumatic Fever (ARF) occurs after an untreated group-A β-streptococcal hemolytic infection of the throat. It is an inflammatory disease of children and young adults but it also includes adults. ARF is a multi-system disease that may involve heart, joints, central nerve system, skin, kidney and pulmonary (1,2). There is no single diagnosis factor and the diagnosis of ARE relies on combinations of many clinical and laboratory findings (3,4). The first step in treatment is the eradication of the streptococcus to prevent subsequent episode of acute streptococcal laryngitis and recurrent ARF (2,5). ARF was not studied in Khorassan (Iran) and there was no updated information on the subject. In this paper results of comprehensive study of ARF in adults of Khorassan is reported. In our study total of 56 patients, including 39 males (70%) and 17 females (30%), with ARF were considered. Their age ranged from 14 to 50 years. Revised Jones criteria were our primary Guidelines for diagnosis. The incidence of cardit in this group of patients with ARF was 40.30%. In all incidence cardit occurred within the first 3 weeks of attack. 92.98% of patients with ARF manifested Arthritis. It mostly involved knees, ankles and wrists. Our study is of prospective type for the period 1997-2000. The results were compared with similar results of a developed country.

Oral health is one of the most important sector of public and personal health. Information on oral hygiene starus regarding to DMFT (Decayed, Missed, Filled Teeth) as essential for pupils' heath education programs. This study was carried out to assess the dental health and to determine the relationship berween the pupil's DMFT and the use of toothbrush, the parents, literacy and family size. This study was conducted on 300 pupils studying in the city of Ahwaz. They were 120 girls and 180 boys. The study was cross sectional design and sudjects were chosen within a cluster random sampling. Data was collected using a questionnaire. Results showed the mean DMFT score of 1.98. Regular use of toothbrush among boys and girls was reported 7% and 14%respectively. No significant differences were found between use of toothbrush and dental decay with parent's litercay. However. There was a significant association DMFT score and number of children in the family (p = 0.007). In conclusion, oral hygiene status amoung pupils in this community is low and health education programs particularly for more at risk groups is recommended.