A STUDY ON CYTOKINE PRODUCTION IN PATIENTS WITH ACUTE BRUCELLOSIS

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HAGHIRIZADEH ROUDANI M.; ESLAMI M.B.; ALAVI M.; PEZESHKI M.

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Journal: Jundishapur Scientific Medical Journal Year:2002 | Volume:- | Issue:34 Page(s): 20-24

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Title

A STUDY ON CYTOKINE PRODUCTION IN PATIENTS WITH ACUTE BRUCELLOSIS

Author(s)

HAGHIRIZADEH ROUDANI M. | ESLAMI M.B. | ALAVI M. | PEZESHKI M. | Issue Writer Certificate

Keywords

ACUTE BRUCELLOSISQ3

CYTOKINEQ2

IL - 12Q2

IL-2Q3

IFN-Q4

IL-4Q2

IL-10Q2

Abstract

Cytokines are secreted as the molecular products of different cells in particular T - lymphocyte which contribute in the processes of immune response. Brucellosis is caused by intracellular bacteria and as such the cell-mediated immunity (C.M.I) plays a crucial role in immune responses during the course of infection. Thus a study on CYTOKINE production among patients with brucellosis may provide valuable information regarding the function of C.M.I in this disease.71 patients with ACUTE BRUCELLOSIS and 12 normal apparanth healthy medical students and blood donors took part in this investigation. Diagnosis of the disease was based on case history, clinical examination and serological tests. The levels of IL-12, IL-2, IFN- ,g IL-4 and IL-10 in serum were measured by ELISA. The results indicated that the levels of IL - 2, and IL - 4 in the sera of patients had increased slightly. Among all CYTOKINEs, mean IFN-g level showed the highest increase in patients. The levels of IL- 12 and IL - 10 in the sera of patients did not show any appreciable difference with those of normal controls. These results indicated a Th1 type of immune response in patients with ACUTE BRUCELLOSIS.

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APA: Copy

HAGHIRIZADEH ROUDANI, M., ESLAMI, M.B., ALAVI, M., & PEZESHKI, M.. (2002). A STUDY ON CYTOKINE PRODUCTION IN PATIENTS WITH ACUTE BRUCELLOSIS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, -(34), 20-24. SID. https://sid.ir/paper/395342/en

Vancouver: Copy

HAGHIRIZADEH ROUDANI M., ESLAMI M.B., ALAVI M., PEZESHKI M.. A STUDY ON CYTOKINE PRODUCTION IN PATIENTS WITH ACUTE BRUCELLOSIS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2002;-(34):20-24. Available from: https://sid.ir/paper/395342/en

IEEE: Copy

M. HAGHIRIZADEH ROUDANI, M.B. ESLAMI, M. ALAVI, and M. PEZESHKI, “A STUDY ON CYTOKINE PRODUCTION IN PATIENTS WITH ACUTE BRUCELLOSIS,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. -, no. 34, pp. 20–24, 2002, [Online]. Available: https://sid.ir/paper/395342/en

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