Input wet air or process air is dried in a rotary dehumidifier, using solid desiccant particles that are a means to the dehumidification of indoor air. The humidity amount on the surface of the desiccant is increased during the dehumidification process and is adsorbed by a regeneration air stream, which is ultimately exhausted to ambient. In this study, the effect of the Ackermann heat transfer correction factor was investigated by using mathematical modeling of a solid desiccant wheel, as well as mass, energy and momentum balances on air and wet solid particles of the desiccant for the process and regeneration of an air stream. The results indicated that the dehumidification rate, along with the desiccant wheel is dependent on humidity ratio, air velocity and the mass and heat transfer from the air stream to the desiccant bed and the Ackermann correction factor. By increasing the input air relative to the humidity and temperature by more than 50% and 95°C, the respectively, the Ackermann factor corrects the heat transfer coefficient by up to 4%. The comparison between the amount of humidity ratio, exit and inlet temperature and air stream velocity, in the adsorption part of the rotary desiccant wheel showed that the velocity of the exit air stream from the wheel is increased, due to the variation of humidity, temperature and pressure depletion. This mathematical model is also capable of depicting the details of superficial humidity and the temperature of the air stream into the desiccant wheel channels in both adsorption and regeneration parts, as periodic profiles.