In the recent years, Cognitive Theory of Stress (Lazarus, 1991) is presented as a theory for adulthood. This research examined the relationship between stress, cognitive appraisal and coping and the role of this relationship in affective-behavioral symptoms and physical and psychosocial health in children. We used a stratified random sampling procedure in recruiting 413 fifth grade school children in the city of Tehran (220 girls & 193 boys). Children responded to the Children's Perception of Interparental Conflict (CPIC) scale, mothers responded to the overt hostility questionnaire of O'Leary - Porter Scale (OPS) and the Child Health Questionnaire (CHQ), and mothers and teachers responded to the Strengths and Difficulties Questionnaire (SDQ). Results indicated the relationship between marital conflict with children's appraisals of interparental conflict and cognitive coping. Also we found that marital conflict and children's appraisals and coping can predict their psychopathological symptoms and health. In addition, marital conflict and children's appraisal of interparental conflict interact to predict their affective behavioral symptoms. The results in the form of Cognitive-Contextual Framework, Stress-Appraisal- Coping Theory and Developmental Systems Perspective in child psychopathology, confirm the independent and interactional role of two risk factors, marital conflict and children's negative appraisals, in their psychopathological symptoms and health problems.