Objectives: The purpose of the present study has been assessing life satisfaction as an indicator of positive attitude towards life.Method: Multidimensional Students' Life Satisfaction Scale (MSLSS) was used for 200 high school students (100 boys and 100 girls) with three educational field of study: mathematics, science, and humanities in districts three and five of Isfahan city. They were selected on a randomized multi-stage cluster sampling. Data were then analyzed using t-test, Pearson correlation coefficient, one-way analysis of variance, and factor analysis.Results: Cronbach's Alpha in all subjects, male students, and female students were 0.863, 0.844 and 0.884 respectively. Furthermore, the reliability of the instrument was considered acceptable for the educational districts (of three and five) as well as among the three educational study fields (mathematics, science, and humanities).Reliability of five research subscales: friends, self, school, family, and living environment were also reported as acceptable. Factor analysis indicated that items of instrument could be reduced to five factors reflecting construct validity.Conclusion: This scale can be used as a reliable measure in the high school students in Isfaban.