Background and Objectives: This study was conducted to determine natural concentration of heavy metals and their pollution risk using pollution indices in a 2000 km2 area in central Zanjan.Materials and Methods: Soil samples (N=241) was taken from 0-10 cm depth based on gridding procedure in a completely randomized design. Geometric means of 53 natural soil samples were used to determine heavy metals background concentration in the area.Results: Results showed that the background concentration for Fe, Mn, Co, Cr, Ni, Cu, Zn, Pb and Cd were 16509, 628.4, 24.2, 20, 40.7, 27, 91.8, 57.8 and 0.25 mgkg-1, respectively. The means of enrichment factor for Cd, Zn, Pb, Cu, Ni, Cr, Co and Mn were found 4.20, 2.16, 1.69, 1.64, 1.19, 1.17, 1.04 and 1.02, respectively. The highest enrichment factor for Cd (12.07), Zn (5.26), Pb (4.82) and Cu (3.47) was observed in urban area. In all land uses studied, the geo-accumulation index was negative for the elements Fe, Mn, Co, Cr and Ni, indicating that the study area is categorized in non-polluted soil groups. However, the geo-accumulation index for Pb, Zn, Cd and Cu varied in urban land uses was positive. The pollution index for Cd and Zn under agriculture (3.01 and 1.83), rangeland (3.33 and 1.60) and urban (9.86 and 4.35) land uses were higher than other elements studied. Moreover, the lowest pollution indexes in all land uses were attributed to the metals Fe, Mn, Co and Cr. The mean of potential of ecological risk in agriculture, rangeland and urban land uses were 114.09, 122.08 and 339.62, respectively; in which the urban land use showed the highest potential of ecological risk for inhabitants of the area.Conclusion: The results show that urban land has the highest pollution index and this may be due to urbanization activities such as transport and traffic and nearby factories of Zanjan city.