Avicenna Journal of Clinical Medicine
Year:2002 | Volume:8 | Issue:4 (SN 22)|Papers Count:16

Demodex folliculorum is an obligate parasite of human pilosebaceous follicle. Though attempts to elucidate the role of demodex in rosacea have produced conflicting results but several studies have suggested that this mite play a role in rosacea.This is a comparative, descriptive cross - sectional study that carried out on 39 rosacea and 41 non rosacea patients. These patients have biopsied in Department of Dermatology of Hamadan Sina Hospital in 5 years during 1993-1998. The mean of demodex F. in the skin face of rosacea was 1.103 and for non-rosacea patients was 0.171. This difference from statistical aspect was meaningful (P<0.05). There was no difference in mean of demodex in both sexes of rosacea patients (P>0.05). The mean of demodex in patients over 40 year in comparison of below 40 years was meaningful (P<0.05). In this study the mean of demodex in rosacea was higher than that of control group. But a prospective study with normal skin as control group is needed to clarify the exact role of demodex in rosacea.

Egg white is one of the important nutrients that frequently induces allergic reactions, particulary in atopic children .The proteins of egg white are common causes of hyper - sensitivity symptoms among atopic individuals so in the way of studying the allergy to egg , it is essential to purify egg white proteins . In the present study, ion exchange chromatography, immune electrophoresis (IE) and polyacrylamid gel electrophoresis (SDS-PAGE) were used for separation and purification of egg white proteins. Following ion exchange chromatography, three fractions including: F1, F2, F3 were distinguished and isolated in concrete pHs. The isolated fractions were analysed by SDS - PAGE and IE. The results indicated several protein bands in F1, a single protein band in F2 and a major protein band with minor impurity in F3. Also molecular weight of the isolated fractions was determined by SDS-PAGE, so F2 and F3 identified as ovotransferrin (conalbumin) and ovalbumin respectively. The study indicated that ovotransferrin was highly pure, whereas ovalbumin included a little impurity.

Establishment of coronary care units (CCU) causes decreasing in hospital's mortality after cardiac arrest, because life threatening arrhythmias could be reversible by effective measures. The aim of this study was ascertainment of short term (in hospital) prognosis of patients who admitted in Hamadan's Ekbatan Hospital's CCU and experienced cardio pulmonary resuscitation (CPR) after cardiac arrest. This study was descriptive, cross-sectional and prospective and included 101 patients who admitted in CCU since 1997 to 1998 and experienced at least one CPR. In present study the most common mechanism of cardiac arrest in successful CPR was ventricular fibrillation and in unsuccessful CPR was asystol and bradycardia. 20. 8% of patients who experienced cardiac arrest had successful CPR and discharged from hospital. 20.8% of patients had successful CPR and hospital discharge which in comparison to the same studies is acceptable and indicate good quality of aforementioned CCU.

The purpose of this study was to evaluate the ability and accuracy of imaging in the diagnosis of the bone tumors comparing to the results of pathology. It was conducted by assessment of the records of 71 patients (between 6-65 years of age) with primary diagnosis of bone tumors referred to the orthopedy department of Sina and Shariatti hospital in Tehran during two years (1993-1994) who had completed chart, lab data and radiographic studies as well as definite pathologic diagnosis. According to radiologic finding of each patient, three differential diagnoses were made and divided into the benign and malignant groups and then compared with the result of pathology, using Mc Nemar statistical test. Furthermore the frequency of bone tumors in these patients was assessed. Our findings showed that the most frequent benign and malignant tumors among these patients were giant cell tumor (18.3%) and Osteosarcoma (5.6%) and Uwing sarcoma (5.6%), respectively. Moreover the frequency of all the tumors including benign and malignant lesions in 6-25 year old patients was more than other groups. Comparing the radiologic finding with the result of biopsy showed that if all the three radiological diagnosis conformed a benign lesion, we can expect the tumor is benign with the positive predictive value of 100%. In our study these included 88% of being tumors and 65% of all the tumors that were reviewed. We can therefore conduct the diagnosis and therapulic processes in only one session to avoid further cost and time.

Herpes Zoster is rather a common skin disorder. It is the consequence of late reactivation of dormant varicella zoster virus in person who has already suffered from chickenpox. From the clinical point of view it is limited to one dermatome. the aim of this study was the survey of clinical and demographic features of Herpes Zoster patients who referred to the Department of Dermatology of Sina hospital of Hamadan between 1994-1998 . This is a kind of descriptive retrospective cross-sectional study which the essential information was gathered by referring to the patients file and then the obtained information was analyzed. From 10486 patients that referred to the hospital, 173 (16%) cases had Herpes Zoster. 54.9% of them were male and the rest were female. The most prevalence group were 60-69 year-old patients (20.2%). The distribution of lesions were more common in thorasic dermatome (41%) and then cervical dermatome (24.3%), lumbosacral (23.7%) and trigeminal (11.6%). 47.4% of the lesions were on the right and 48% were on the left and 4.6% in both side of the body. The highest frequency of the Herpes Zoster was in summer and the lowest one in spring. This study shows that the frequency of Herpes Zoster is higher among men than women. Also the number of patients in the young age group was considerable compared to the other study which carried out in the developed countries.

For several years, scientists tried to find antioxidant compounds that inhibit the low density lipoprotein (LDL) oxidation reaction but have no destructive effects. Vitamin C and vitamin E can inhibit LDL oxidation. Volatile oils possess herbal sources and because of lipophilic properties can enter LDL and their antioxidant effects have not been known. The aim of this study is possible use of herbal products such as volatile oils in preventing or treating atherosclerosis. Because the probable effects of volatile oils on the affinity of LDL to its receptor, this affinity can be influenced and the modification of LDL and atherogenesis be prevented. In this study, antioxidant properties of various concentrations of three volatile oils include: P-cymol, Limonene and Thymol , and vitamin C on the affinity of natural-LDL and oxidized-LDL(with Cu+2) to its receptor in bovine adrenal tissue cells have been investigated in the presence of labeled-LDL with fluoresein isothiocyanate (FITC). First, after purification of LDL-solvent of normal serum and incubation it with these compounds, oxidation reaction performed and LDL-solvent was labeled with FITC, and then all solvents were added to the medium that contains adrenal tissue cells(with LDL-receptor). Finally, fluorescence intensity of supernatant of each sample was determined in spectrofluorometer. Also, the effects of the best concentration of vitamin C (obtained in this study) with each one of these compounds was studied. Results showed that vitamin C in 100 micromolar concentration has the greatest effect on the increasing affinity of LDL to its receptor (for natural- LDL 18.5% and for oxidized-LDL 62%). Among the volatile oils used, "Thymol" had the best effect (for natural-LDL 27% and for oxidized-LDL 50%). In studying the effects of these three volatile oils with the best concentration of vitamin C (100 micromolar) , "Thymol" had the highest effect on this affinity. These finding showed that some compounds probably can change the affinity of LDL to its receptor and thus may prevent formation of atherosclerosis.

There was no documented information about the subject of this survey in the country. Regarding the importance of these lesions and their pathologic changes and considering this epidemiologic survey as a base for future analytical researches, the survey seemed to be justified. A cross - sectional descriptive study was designed and with a cluster - random sampling the 350 patients selected in five zone of Hamadan, who were interviewed, and clinically examined at their homes in 1997. 78.8% of the surveyed patients had at least one denture induced soft tissue lesion. The most common lesion was inflammatory fibrous hyperplasia (26.8%) and Angular chellitis had the least prevalence(2.5%). Other soft tissue changes lied between these two rates. The denture induced soft tissue lesions had considerably more prevalence than any reports up to the time of survey which need more investigation.

Vitiligo is a melanocytic disorder that diagnosed by depigmented skin patches and hairs that may appear with neuro-ophthalmo-labyrintic involvement. Association with some other autoimmune disorders such as diabetes, thyroiditis and gastric parietal cells antibody has been observed. Past researches mentioned that association of vitiligo with diabetes were between 1% and 7.1%.The purpose of this study was to determine the prevalence of diabetes and glucose abnormalities in patients with vitiligo in Kerman in 1999. This is a cross sectional case with control study on 125 vitiliginised patients that has been consecutively referred to dermatology clinic. Prevalence of diabetes and glucose abnormalities in case group with vitiligo has been evaluated with some variables of age, sex, and duration of disease but only family history of the disease was significantly positive. Diabetes and glucose tolerance abnormality in cases with vitiligo was obtained as 8.2% whish are more than normal cases.

The aim of this study was the comparison of efficacy of two nonsurgical methods in management of patients with acute ligamentous injury (Sprain) of ankle which are "Primary immobilization" and "Early active functional treatment". This study consists of 200 patients with acute ankle sprain who referred to emergency ward and clinic of orthopedics of Mobasher Kashani Hospital of Hamadan. This was a clinical trial study. 100 patients were managed with primary immobilization and the other 100 patients were treated with active functional treatment. Information was gathered with a questionnaire that complete during a primary and later serial physical examinations. Datum were analyzed manually and then for quantitative variables, t-test and for qualitative variables, fisher exact test were performed. Results of this study revealed that the mean time for return to normal daily activities in patients with grade I of ankle sprain that managed with "primary immobilization" was 14.5 days Vs 14.1 days in patients that managed with "early active functional treatment". In addition, the mean time for return to professional or athletic activities, in patients with grade I and II of ankle sprain in two groups had not a significant difference. But the mean time for return to normal daily activities in patients with grade II of ankle sprain with "primary immobilizatin" and "early active functional treatment" were 27.4 and 21.38 days respectively. In two groups there was no difference in level of functional activity on 90 days after treatment. Finally we could say that there was no difference between these two methods in approaching the patients to their pre-injury level of activity.

The purpose of this study was to examine relationship between waist to hip ratio (WHR) with serum lipids and blood pressure. This was a cross sectional study. Sample study contained 62 women aged 25-40 years who worked in the hospital of Ali ibn Abitaleb in Rafsanjan. This group was assessed using an interview and blood lipids and blood pressure measurement. A tape was used to measure waist and hip circumference and height. Blood pressure was determined with a mercury manometer. Serum cholesterol, triglyceride, and HDL were measured with autoanalyzer and calculated with formula of LDL=HDL TG/2.2 According to the results, no significant relationship was observed between WHR with serum lipids and blood pressure. While it showed statistically significant relationship between WHR and weight (P<0.001). It seems lack of statistical significant relationship between WHR with lipids and blood pressure was due to use healthy and age of samples. From these finding it can be concluded that the relationship between WHR and the studied variables is significant when the studied individuals are older or have other diseases. Further studies oare required to clarify this relationship in the healthy samples.

Aspergillosis is an important systemic fungal infection with various clinical forms and its clinical and mycological diagnosis is difficult and complicated but its serodiagnosis is simple and useful for some clinical forms (aspergillomma and allergic aspergillosis). This study was performed for preparing metabolic antigen and related antiserum of the most important agent of aspergillosis, "Aspergillus fumigatus", for using in serodiagnosing the disease. The fungus was isolated from the patients, and cultured in glucose peptone broth for 5 weeks. After removing the fungal mass, the secretary (metabolic) antigens was isolated and processed and injected to rabbit. Antisera were evaluated by double- diffusion (DD). Prepared antigen was able to immunize rabbits and reacted with rabbit and patient's sera in immunodiffusion. Number and pattern of the bands was comparable with standard antigen and antiserum. After standardization, this antigen, it can be a useful reagent to serodiagnosis of aspergillosis by lower cost and more accessibility.

Maxillomandibular fixation (MMF) method is performed in maxillary or mandibular fractures , plastic surgeries and congenitally anomaly of mandibular. Post operative nausea and vomiting due to anesthesia and opioids is one of the most important complications. This study performed for determination of metoclopramide and metoclopramid plus dexamethasone effects for reduction of nausea and vomiting after maxillomandibular fixation surgery in the patients with mandibular fractures. In this double-blind clinical trial, 60 patients candidated to maxillomandibular fixation surgery were randomized into two treating groups (A: Metoclopramide alone, B: Metoclopramide + Dexamethasone) and evaluated in nausea and vomiting rates after operation. The patients were followed in three stages in the operation room, in recovery room, and in the ward upto 24 hours. In first stage, 30% of patients in group A and 6% of patients in group B encountered post operative nausea and vomiting. During second stage, these rates were 17% in group A and zero for group B. Non of the patients in both groups, encountered post operative nausea and vomiting in third stage of following. The findings indicate that combination of metoclopramide and dexamethasone can decrease post operative nausea and vomiting incidence rates effectively. Suitable tolerance of patients to drug and less complications of dexamethasone compared risk of post operative vomiting are more factors that account for complication therapy with dexamethasone and other antiemetic agents. However, expand use of this method needs more studied.