Journal of Kerman University of Medical Sciences
Year:2004 | Volume:11 | Issue:2|Papers Count:11

Adult cardiovascular disease has its roots in childhood, Various surveys have shown a significant correlation between early atherosclerotic changes indentified at autopsy of children and young adults, and both total cholesterol (TC) and low-density lipoprotein (LDL cholesterol) levels. The hypercholesterolemic neonates time for diagnosis of high risk neonate infants. The aim of this study is to compare the lipids and lipoproteins levels of cord blood with the same parameters in Nelson textbook of pediatrics. This is a cross sectional study on umbilical cord blood of 243 full term newborn infants (114 females and 129 males) who were born at the Razi Hospital of Ahwas University from March to September of 2002. For the collection of data we used the nonprobabilitic sampling. Complicated and abnormal cases were eliminated. The mean of TC, LDL-C, HDL-C and TG were: 81.02±19.75 mg/dl, 48.92±16.39 mg/dl, 25.09±7.34 mg/dl and 42±29.10 mg/dl. The result showed that the mean of T.c., WL C and TG. Was significantly more than that of Nelson textbook (P=0.0001).The mean of HDL C. was significantly less than that of Nelson textbook P=0.0001). Also the prevalence of hypercholesterolemia in neonatal infants is significantly more than that of Nelson textbook. In this study, the mean of lipids and lipoproteins was compared between males and females. The mean of TC and WL C. in females is significantly more than male neonates (P=0.016 and P0.007). Therefore, this community is at high risk. Because the neonates with hypercholesterolemia will be more liable to face this problem in adulthood, measuring of cord blood lipids and lipoproteins is a priority in this community. Lipids profiles of parents and other 1st (-degree relatives are also necessary to establish whether there is a dominantly inherited defect responsible for the hypercholoesterole, mia.

Caffeine, dose dependently can reinforce or deteriorate learning. In previous studies, the effect of glucose on decreasing of amnesia was investigated In this study, the effect of caffeine on three phases of learning and also probable interference of glucose in mice were examined by using of passive avoidance learning. Male albino mice were examined as follows: 1. test group: a) this group received electric shock and caffeine (25, 50, 100 mg/kg) without dextrose regimen, b) this group received electric shock and caffeine with dextrose regimen, 2. Control group (saline). In all groups, the latency period of moving from a cubic platform to the wire floor of apparatus in three steps was studied. Data were analysed by non- parametric Mann - Whitney U and Kruskall- Wallis H-tests. Differences between points of data were statistically considered significant at p<0.05. Caffeine in low dose (25 mg/kg) increased retention time in consolidation phase but in high dose (100mg/kg) compared to other doses, it decreased the retention time in phases of learning. According to the results, the negative effect of caffeine in high dose on all phases of memory can be reversed with long-term dextrose regimen.

The floor plate is a small group of cells located at the ventral midline of neural tube. During early neurogenesis the floor plate plays critical role (s) in differentiation of ventral portion of neural tube. The purpose of this study was to determine the distribution of glycoconjugates in floor plate as well as underlying mesoderm (notochord) and their inductive activities in mouse embryos. Formalin fixed sections embedded in paraffin from 10 to 14 days old Balb/C mouse embryos were processed for histochemical studies by using five different horseradish peroxidase (HRP) labeled lectins including; Glycin max (SBA) specific for Gal and GalNac terminal sugar, Vicia Villosa (VVA) and Arachis hypogaea (peanut) for GalNac, Ulex europeus (UEA-1) and Lotus tetragonolobus (LTA) for α- L-fucose. Our results showed that SBA sensitive glycocorifugates react and change in floor plate, notochordal cells and surrounding extracellular matrix and these changes were significant (P<0.05). Extensive differences between GalNac sensitive lectins were observed during motoneuron differentiation. There was no reaction with other tested GalNac lectins. Furthermore we observed significant changes (P<0.05) infucose glycocorifugates during notochordal development. The results suggest that the timing and distribution of SBA sensitive glycocorifugates may play α key role (s) in interactions and subsequent formation of atijacent tissues such as floor plate and notochord during critical period of morphogenesis. Our finding also showed that glycoconjugates with fucose terminal sugar may play α role (s) in notochordal development but probably have no function on floor plate development.

Laryngeal cancer is a disease of old age and the most common age of presentation is 6Th.7Th decade of life. This disease is more common in men, but male to female ratio has been decreased from 15:1 to 4:1 during the last forty years. The most common risk factors are cigarette smoking and alcohol consumption. This cross - sectional study carried out to determine the age of laryngeal cancer from 1375 to 1380. 98 patients with confirmed diagnosis of laryngeal cancer (83 men and 15 women) with the mean age of 57.5±12.9 were studied. Patients were divided into two groups: addict and non -addict. Mean age of the addicted, patients was 10.5 years less than that of non- addicted. The average age of addicted patients was 55.1±12.1 and that of non-addicted patients was 65.6±12.8 (P=0.0001).The rate of laryngeal cancer under the age of 40 has been reported, less than 2% in international reports, but in the present study it was 6.5% and all of them were opium addicted. The number of cigarette smoked daily and length of smoking were significantly lower in addicted patients (21.5±7 cigarette daily and 25.2±11.1 years) comparing with non-addicted patients (21.5±9.5 cigarette daily and 37.4±11.9 years). Therefore the mean age of incidence in our patients is lower than that reported in literature and it maybe due to opium consumption.

Neurological effects of Valeriana officinal is having been recognized for many years. In this study, the anticonvulsant activity of methanolie extract of the plant were investigated in mice Picrotoxin with doses of 6 and 12.5 mg/kg were used for induction of seizures. The effects of different doses of methanolic extract of the plant on the variation of beginning time of seizures, the incidence of tonic and clonic seizures and mortality rate were determined. The beginning time of tonic seizures induced by picrotoxin (6 & 12.5 mg/kg I.P.) were delayed significantly in group which received extract (50 mg/kg I.P.) 20 min. before picrotoxin administration. Latency of beginning time of tonic seizures in mice which receive picrotoxin 6mg/kg were increased significantly from 10.58 min to 15 min (P<0.05) and in case of 12mg/kg of picrotoxin from 5.87 to 10.82 min.(P<0.01). The incidence of clonic seizures and mortality rate were decreased in this group of animals (P<0.05, P<0.01). The results indicated that valerian extract may be effective on generalized tonic, cloinc and tonic - clonic seizures and the dose of 50 mg/kg was enough to produce effective concentration for anticonvulsive activity of the extract in mice.

In this study antimicrobial effects of Salivia mirzayanii and Saliva atropatana were evaluated against sixgram-positive and gram-negative bacteria by immersion bioautography, cylinder plate and tube d ilution methods separately. In bioautography method, essential oils of Salvia mirzayanii and Salvia atropatana were separated on silicagel TLC plates by toluene-ethyl acetate (93-7). In cylander plate and tube dilution method, methanolic (80%) and aqua extracts were taken by maceration method. After concentrating the extracts, they were dried, then the 50, 25, 12.5, 6.25, 3.125 and 1.562 mg/ml distilled water solution of the, dried were used for searching antimicrobial effects. Essential oil and extract of Salvia mirzayanii against E.coli, S. aureus, K. pneumonia, B. subtilis and P. aeroginosa in different dilutions were effective and essential oil and extract of Salvia atropatana against E.coli, S. aureus, S. epidermidis and B. subtilis were effective too.

The McGill Pain Questionnaire (MPQ) consists primarily of3 major classes of word descriptors -sensory, affective and evaluative that is used by patients to specify subjective pain experience. It also contains an intensity scale and other items to determine the properties of pain experience. The questionnaire was designed to provide quantitative measures of clinical pain that can be treated statistically. This paper describes the procedures for administration of the questionnaire and the various measures that can be derived from, an Iranian version in comparison with previous results which were obtained from other countries. The mean and standard deviation of these measures, based on data obtained from 46 neurosurgical patients suffering from several kinds of psychocognitive and emotional status, before and after surgery in Kerman Shahid Bahonar Hospital is presented In addition, an experimental study utilizing the questionnaire Was analyzed in order to describe the nature of the information obtained by an Iranian version. The data, taken together, indicate that the McGill Pain Questionnaire provides quantitative information that can be treated statistically, and is sufficiently sensitive to detect differences among different methods of pain relieve which work with Iranian pain patients. These results show that the dimensions are close to the previous studies conducted by Melzak and Torgerson (1971) and Ebrahimi-Nejad (1997).

Actinomycosis is a chronic and less common infectious process that established by Actinomyces israilii. Involvement of faciocervical region is more common than thoracic and visceral types and typically involves the angle of mandible and with less occurrence rate the upper jaw may also be involved Periodical lesions of maxilla that involved in this process by Actinomyces israilii are rare and common site of them is the periapical area of central incisors of maxilla. A subject is a 31 year old woman who after multiple effort of endodontic and surgical procedures eventually with meticolous surgical debridement and pathologic examination with diagnosis of periapical actinomycosis was treated with penicilin for 10 weeks and after that showed no sign and symptom in involved area.