Nowadays one of the arguments that have been raised in the world of nanotechnologies is moving or manipulation of nanoparticles. This discussion is important because the displacement of nanoparticles can make nanoparticle structurally different than what is currently available. So to achieve this goal, the atomic force microscope probe is used as manipulator. By the use of atomic force microscope probe, nanoparticles by pulling or pushing on the surface, are displaced and brought to the desired point. If the applied force was too much, Nanoparticle has been continued movement (sliding or rolling) after standing atomic force microscopy probes and away from the desired point. On the other hand, if the force is low, so that it can’t overcome the static friction force, Nanoparticles will not move. So finding the optimal force is important in nanomanipulation. In this paper, using nanoparticle dynamic simulation, the governing equations on nanoparticle are derived and simulated during manipulation so that they can be used to obtain the critical force and time for gold, yeast and platelets nanoparticles in gaseous, water, alcohol, and plasma environments. By comparing the results obtained in this paper, it is concluded that the movement of particles in different biological environments starts later, and by a force of higher magnitude relative to the gaseous medium.