The purpose of this study was to investigate the effect of group logotherapy on depression, anxiety and quality of life in cancer patients in Ahvaz Big Oil Hospital. The original sample included 60 patients who were selected by matching method. Then 30 patients who scored one standard deviation above the mean in Anxiety Inventory (ANQ), Beck Depression Inventory (BDI) & Quality of Life Questionnaire (QLQ-C30) were selected randomly and divided into two groups (experimental and control). Then 10 sessions of group logotherapy were held for experimental group, but the control group received no intervention. Also MANCOVA was used for analyzing the data. The results revealed that there were significant differences between two groupe on variables (p < 0.001). The depression and anxiety of experimental group were significantly decreased comparing to control group. Also, the quality of life was significantly increased in experimental group in comparison to control group. So, using logotherapy for cancer patients is recommended.