Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Issue Information

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Author(s): 

Shahbazi Yasser

Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    204-208
Measures: 
  • Citations: 

    1
  • Views: 

    163
  • Downloads: 

    87
Abstract: 

Objective(s): The application of synthetic antimicrobial and anti-fungal compounds is reducing in last decades in the food and nutrition fields owing to their various side effects and increasing interest of consumers to eat natural foodstuffs without artificial constituents. Clove (Syzygium aromaticum) has numerous medicinal property including analgesic, antiseptic, stimulants, carminative and natural antihelminitic. The present study was aimed to evaluate the antifungal, antioxidant and antibacterial properties of clove essential oil (CEO) under in-vitro condition. Methods: Antioxidant property of nano emulsion of CEO was evaluated in terms of radical scavenging ability against DPPH free radical. Antibacterial and antifungal effects of nano emulsion of CEO were evaluated using agar disk diffusion assay. Results: Antioxidant property of CEO was found to be 92. 45% ± 5. 49. Based on our findings, the food-borne pathogens were shown the highest sensitivity to the CEO (inhibition zone = 5. 12-14. 34 mm), followed by probiotic microorganism (inhibition zone = 2. 57-4. 44 mm), and fungi (inhibition zone = 2. 13-3. 19 mm), respectively. Conclusions: The results of the present study indicated that nano emulsion of CEO has good antimicrobial and antioxidant property under in-vitro condition.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    209-219
Measures: 
  • Citations: 

    0
  • Views: 

    165
  • Downloads: 

    96
Abstract: 

Magnetic nanoparticles have been highly regarded because of their unique properties, such as hyperthermia, medicine control release, and diagnostic applications. The role of these magnetic nanoparticles as medicine delivery carriers is bolder due to certain properties, in addition to the usual properties of nanomaterials, The main aim of the current paper is to offer a new system for the modification of Fe3O4 (SPIONs) superparamagnetic nanoparticles physically and chemically with polymers through physical retention. These modified nanoparticles have been used to encapsulate cisplatin as an anticancer medicine and the effect of nanocapsulated cisplatin has been studied in lung cancer (A549) cell line. Using ringopening polymerization Triblock copolymer PCL-PEG-PCL was prepared of ɛ-caprolactone (PCL) in the presence of polyethylene glycol (PEG). Magnetic iron nanoparticles were also prepared and identified. Using Fourier Transform Infrared Spectroscopy (FTIR), the bulk features of the copolymers were determined. Nanoparticles loaded with Cisplatin have been ready using the copolymer containing iron superparamagnetic nanoparticles via double emulsion solvent evaporation method and evaluated for medicine entrapment efficiency (%), the quantity of medicine, size, and surface morphology. Cytotoxic tests have been considered using MTT assay method in lung carcinoma (A549)-treated cells. As well as, using scanning electron microscopy, Fourier Transform Infrared Spectroscopy (FTIR) and X-ray powder diffraction (XRD) the particles have been specified. The results of the study in vitro showed that Fe3O4-PCL-PEG nanoparticles did not have a cytotoxic effect and were biocompatible. The anti-proliferative effect of cisplatin encapsulated in magnetic nanoparticles was much earlier faster than pure cisplatin and enhanced the decrease in IC50 rate significantly. The results of the study demonstrated that nanocapsulated cisplatin had a significant cytotoxic and anticancer effect in vitro of the lung cancer cell line and it can be concluded that this approach has the ability to fail some of the main chemotherapy constraints and can be an appropriate approach for future programs in the treatment of lung cancer.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    220-227
Measures: 
  • Citations: 

    0
  • Views: 

    139
  • Downloads: 

    47
Abstract: 

The purpose of this research is designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of CS-NPs were specified respectively through scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). CS-NPs were fabricated based on the ionic gelation method of tripolyphosphate (TPP) and chitosan (CS). The results showed a smooth surface, spherical shape by SEM. The particle size of loaded nanoparticle was 187 nm and zeta potential was found to be 46. 7 mV. Optimum concentration obtained 400 μ g/ml for loading of venom, which leads to LC 86% and EE 91%. Based on the results of the study, it can be concluded that the vipera albicornuta venom loaded CS-NPs may be used as a new antigen delivery system.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    228-233
Measures: 
  • Citations: 

    1
  • Views: 

    136
  • Downloads: 

    65
Abstract: 

Iron oxide nanoparticles (IONPS) have different practical purposes in nanomedicine. These new applications of IONPS have raised risk of exposure of this nanomaterials to humans. Up to the present, all features of IONPS toxicity are not fully characterized after exposure to animals. The aim of the present study is to investigate the acute toxicity effects of IONPS in laboratory animals regarding pathotoxicological analysis and clinical aspects. Twenty four male Wistar rats were selected, and separated into four groups. The first, second, and the third groups received 50, 500, and 5000 mg/kg of IONPS solution orally for five days through gavage, respectively. Animal mortality, clinical sings and body weight were evaluated during the study. Fourteen days after the last administration, rats were euthanized for further investigation for histopathological evaluation. There were no death observed in all groups. High and middle dose of the IONPS caused symptoms like lethargy, ataxia, anorexia, isolation, and respiratory arrhythmia over the period of the study. The subjects of the low dose group showed no signs of toxicity. Specific histopathological complications, like hyaline cast in the kidneys, hyperemia and interstitial thickening in the lungs, hemorrhage in the heart and hepatic degeneration in the liver were observed in high dose group. Thus, it can be concluded that, toxicity of IONPS in rats is dose-dependent. This particular size of IONPS can induce serious pathological abnormalities and clinical symptoms in high dose.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    234-238
Measures: 
  • Citations: 

    0
  • Views: 

    155
  • Downloads: 

    69
Abstract: 

Objective(s): Hyalomma spp. is responsible for transmission of protozoan, bacterial, rickettsial and viral diseases in humans and animals. Recently, there was a wide number of attempts to evaluate and application of nanoparticles for the control of ticks. Methods: The object of this study was to appraise the acaricidal activity of zinc oxide nanoparticles (ZnO NPs) size 15 nm against Hyalomma spp. in vitro. The arcaricidal activity of Zn NPs were evaluated at concentrations of 50, 125 and 250 mg/ml and controls (distilled water and Cypermethrin) following 10, 30 and 60 min of exposure in triplicate and the experiments were performed two spraying and contact methods. Results: The results of this study revealed all concentrations of Zn NPs had acaricidal activity and concentration of 125 mg/ml after 30 minutes exposure and concentration of 250 mg/ml at all exposure times had highest acaricidal effect (100%). The median lethal concentration (LC50) values were 50 mg/ml in 60 min and (LC99) values were 150 mg/ml in 30 min for Hyalomma spp. . The results showed that the spray method was more effective than the contact method. Conclusions: The findings of present study showed that Zn NPs had potent acaricidal effect and recommended as an effective acaricidal agent. However, further in vivo studies are required to evaluate the efficacy of this nanoparticle.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    239-246
Measures: 
  • Citations: 

    0
  • Views: 

    165
  • Downloads: 

    68
Abstract: 

Objective(s): Exosomes are endogenous nanovesicles act as intercellular communication tools which have been considered to utilize as drug delivery systems. As transporting therapeutic molecules into brain has obstacles, preparing exosomes which have the potential to pass through its barriers is great challenge. Methods: Exosomes isolated from cell culture media of U87 glioblastoma cells were characterized. In the next step, paclitaxel (PTX) was loaded into them to investigate the cytotoxicity of this formulation on two cell line of glioblastoma, U87 and T98G. Pharmaceutical characterizations such as size analysis, PTX encapsulation efficiency and FESEM/TEM imaging of exosomes were also evaluated. Results: CD9 as a biomarker of exosomes was detected in extracted samples to confirm the presence of exosomes. Size analysis and electron microscopy imaging proved nano-range of isolated and drug loaded exosomes. The cytotoxicity of empty exosomes of U87 cells was different on U87 and T98 cells. Exosomes diminished cell viability in U87 cells compared with control group while in T98 cell line they didn’ t have any effect on cell viability after 24 or 48 h time intervals. The cytotoxicity of drug loaded exosomes was different at two time intervals where PTX loaded exosomes had no effect or 30 % cell viability decrease on T98 cells after 24 and 48 h, respectively. Conclusions: Increased cytotoxicity of PTX after entrapment into exosomes and BBB transport capability of exosomes promises an appropriate brain drug delivery system for in vivo characterization in GBM animal model.

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Author(s): 

Adabi Mohsen

Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    247-252
Measures: 
  • Citations: 

    2
  • Views: 

    132
  • Downloads: 

    70
Abstract: 

The aim of this work was to develop a simple, selective and sensitive aptasensor for detection of Pb2+ based on hairpin structure of complementary strand (CS) of aptamer (Apt). Screen printed carbon electrode (SPCE) was electrodeposited by gold nanoparticles to be used as the substrate for the immobilization of Apt-CS. Moreover, gold nanoparticles (AuNPs) and thionine were added to increase the sensitivity of the aptasensor. The morphology of SPCE and AuNPs modified SPCE was investigated using scanning electron microscopy (SEM). The SEM results exhibited that the AuNPs were homogeneously distributed on the surface of SPCE. The electrochemical performance of aptasensor was evaluated by means of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) measurements. The electrochemical results indicated that peak current due to the hairpin structure formation of CS decreased in the presence of Pb2+. However, in the absence of Pb2+, peak current was enhanced because of combination of thionine/AuNPs-CS. The designed aptasensor showed a high selectivity toward Pb2+, wide linear range (1-40 nM), low detection limit (374 pM), acceptable reproducibility and good long-term stability.

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    253-260
Measures: 
  • Citations: 

    1
  • Views: 

    131
  • Downloads: 

    53
Abstract: 

Objective(s): According to the effects of nano-ZnO on physiological behaviors in animals, in the present study we have evaluated the effects of nano-ZnO anxiolytic doses on electrocardiogram (ECG) sings changes in the restraint and non-restraint ovariectomized (OVX) female rats. Methods: Female rats (160-180 g) were divided into: control (non-OVX + saline) and OVX groups including: control(saline), nano-ZnO 1, 2. 5 and 5mg/kg, stress of 90 or 180 min + saline and stress of 180 min+ nano-ZnO 2. 5mg/kg. Elevated plus maze (EPM) and hole board apparatus were used to measure of anxiety-like behaviors, thirty min after intraperitoneally injections or stress induction. ECG parameters and serum zinc level were measured in all groups. Results: Ovariectomy induced anxiety and restraint stress in OVX rats increased it in the hole board test. Nano-ZnO 2. 5 and 5 mg/kg improved anxiety-like behaviors in the EPM test. In the stressed rats, nano-ZnO 2. 5 mg/kg improved anxiety-like behavior in the hole board apparatus. Nano-ZnO increased zinc level in a dosedependent manner in the non-restraint OVX rats. Nano-ZnO 1 mg/kg decreased QRS amplitude and all doses decreased QT interval to the level of non-OVX group. Nano-ZnO 5 mg/kg alleviated QTc to the level of non-OVX group. Stress of 90 min increased QT interval while stress of 180 min decreased it. Nano-ZnO after stress induction could alleviate heart rate, R-R-interval and QRS interval to the level of non-OVX group. Conclusion: It seems that nano-ZnO rather than could improve anxiety, lleviated ECG parameters in the restraint and non-restraint OVX rats.

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