Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells

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Fathi Karkan Sonia; DAVARAN SOODABEH; AKBARZADEH ABOLFAZL

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Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:4 Page(s): 209-219

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Title

Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells

Author(s)

Fathi Karkan Sonia | DAVARAN SOODABEH | AKBARZADEH ABOLFAZL | Issue Writer Certificate

Keywords

Cisplatin

Lung cancer

Medicine Delivery

PCL-PEG-PCL

Fe3O4

Superparamagnetic

nanoparticles

Abstract

Magnetic nanoparticles have been highly regarded because of their unique properties, such as hyperthermia, medicine control release, and diagnostic applications. The role of these magnetic nanoparticles as Medicine Delivery carriers is bolder due to certain properties, in addition to the usual properties of nanomaterials, The main aim of the current paper is to offer a new system for the modification of Fe3O4 (SPIONs) Superparamagnetic nanoparticles physically and chemically with polymers through physical retention. These modified nanoparticles have been used to encapsulate Cisplatin as an anticancer medicine and the effect of nanocapsulated Cisplatin has been studied in Lung cancer (A549) cell line. Using ringopening polymerization Triblock copolymer PCL-PEG-PCL was prepared of ɛ-caprolactone (PCL) in the presence of polyethylene glycol (PEG). Magnetic iron nanoparticles were also prepared and identified. Using Fourier Transform Infrared Spectroscopy (FTIR), the bulk features of the copolymers were determined. nanoparticles loaded with Cisplatin have been ready using the copolymer containing iron Superparamagnetic nanoparticles via double emulsion solvent evaporation method and evaluated for medicine entrapment efficiency (%), the quantity of medicine, size, and surface morphology. Cytotoxic tests have been considered using MTT assay method in lung carcinoma (A549)-treated cells. As well as, using scanning electron microscopy, Fourier Transform Infrared Spectroscopy (FTIR) and X-ray powder diffraction (XRD) the particles have been specified. The results of the study in vitro showed that Fe3O4-PCL-PEG nanoparticles did not have a cytotoxic effect and were biocompatible. The anti-proliferative effect of Cisplatin encapsulated in magnetic nanoparticles was much earlier faster than pure Cisplatin and enhanced the decrease in IC50 rate significantly. The results of the study demonstrated that nanocapsulated Cisplatin had a significant cytotoxic and anticancer effect in vitro of the Lung cancer cell line and it can be concluded that this approach has the ability to fail some of the main chemotherapy constraints and can be an appropriate approach for future programs in the treatment of Lung cancer.

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APA: Copy

DAVARAN, SOODABEH, & AKBARZADEH, ABOLFAZL. (2019). Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells. NANOMEDICINE RESEARCH JOURNAL, 4(4), 209-219. SID. https://sid.ir/paper/754570/en

Vancouver: Copy

DAVARAN SOODABEH, AKBARZADEH ABOLFAZL. Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(4):209-219. Available from: https://sid.ir/paper/754570/en

IEEE: Copy

SOODABEH DAVARAN, and ABOLFAZL AKBARZADEH, “Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 4, pp. 209–219, 2019, [Online]. Available: https://sid.ir/paper/754570/en

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