In a 2-years field study, wheat growth pattern and grain yield as affected by nitrogen (N) rates were evaluated under varied irrigation conditions at Shiraz University during 2013-15 growing seasons. The treatments included irrigation at four levels (normal irrigation, irrigation cutting at grain filling and spike emergence until end of growing season, and rainfed conditions) in the main plots and six N levels: 0, 75, 150, 225, 300 and 375 kg. ha-1 arranging in a split plot experiment based on randomized complete block design. The results showed that in both years, the highest plant height at anthesis and ripening stages in all irrigation treatments, except rain fed, were observed in 300 kg N ha-1, while the highest plant height in rain fed was achieved in 225 kg N ha-1 treatment for all sampling stages. In all irrigation treatments, except rain fed, the plots receiving more N had the higher leaf area index for all growing stages. As water deficit was applied and intensified, the less N fertilizer was needed for achieving the higher dry matter production; so that the highest final dry matter in normal irrigation, irrigation cutting at grain filling and spike emergence and rain fed conditions for both years were obtained from 225, 225, 150 and 75 kg N ha-1, by 1195. 1, 1115. 2, 931. 1 kg. ha-1 and 517. 6 at the first and by 1015. 8, 957. 9, 791. 5 kg ha-1 and 389. 9 kg N ha-1 at the second year, respectively. Irrigation cutting in grain filling, ear emergence and rain fed were respectively associated with 14. 2%, 39. 7% and 74. 1% reduction in grain yield, compared to control. In both years, the highest SPAD index was observed from rain fed conditions and 375 kg N ha-1, and the highest grain yield was observed in normal irrigation with 150 kg N ha-1 by 568. 1 and 515. 5 kg ha-1 at the first and second years, respectively. In general, the results revealed that although the highest N levels increased growth, especially under normal conditions, for achieving the highest grain yield, 150 and 75 kg N ha-1 is required for normal and rainfed conditions, respectively.