In this paper, we have used the meteorological data of Isfehan, Kashan, Shahreza, Khorobiabanak, Golpayegan and Nain stations. The purpose of this article is representing a simple method to calculate potential evapotranspiration and to compute the evapotranspirated amounts by statistical methods and effective climatic parameters in evaporation. In this method, it was used Multiple Regression and data of evaporation pan as a dependent variable and temperature, saturation deficit, wind speed and relative humidity factors as an independent variables. Then, it was estimated the potential evapotranspiration values for study stations by equation of five variables. So that, temperature, saturation deficit, wind speed and relative humidity, it is computable the evapotranspiration values. However, the Results of this method have a reasonable similarity with evaporated values of pan. For example, this correlation coefficient is reasonable about one percent in Isfehan station. In addition, the results of the Potential Evapotranspiration regionalization have suggested that the increase of the Evapotranspiration values from west to east and also north to south so that in east parts of province (Khorobiabanak and Nain station), this phenomenon reaches to its own pick because of decreasing vegetations and increasing temperature.