Since women in today’s society have multiple and sometimes conflicting roles, the study of their mental health is particularly important. One of the factors affecting mental health is gender role. In the present study, the relationship between gender role (masculinity and femininity) and mental health has been investigated. The aim of the present research is to identify the relationship between gender role (masculinity and femininity) and mental health and its Components (somatic symptoms, anxiety, dysfunction and depression) in Employed Women in Tehran. To do this, a sample consisting of 500 employed women in offices, organizations and administrative companies of Tehran city were selected through random stratified sampling. All subjects answered all items of Goldberg’s (1972) General Health Questionnaire (GHO) and Bem’s (1981) sex role inventory (short form). These Two tests have high reliability and validity. To analyze data statistically, Pearson`s correlation coefficient and multiple regression analysis were employed. The results of the research indicated that femininity and masculinity have significant positive correlation with each other. Femininity has also a negative correlation with problems in mental health, anxiety, dysfunction and depression, but has no correlation with somatic symptoms. Masculinity has a significant negative correlation with mental health and dysfunction; it has no significant correlation with somatic symptoms, anxiety and depression. In addition, the results of regression analysis showed that masculinity has no significant role in explanation of the variance of mental health and its components (somatic symptoms, anxiety, dysfunction and depression). The results showed that in terms of mental health, working women are in a good condition. Therefore, we can conclude that the employment of women outside the house is useful. Thus, officials are expected to create more employment opportunities for women and provide mental health, satisfaction and self-esteem for them.