In this study, the amount of total phenol, chlorogenic acid, catechin, quercetin, phloridzin, cyanidin and antioxidant activity of apple (Malus domestica) skin and flesh of six Iranian cultivars, including: ‘Golab Kohanz’, ‘Sib Torsh Dirras’, ‘Ghara Yapragh’, ‘Torkman’, ‘Ghezel Alma’ and ‘Abbasi Mashhad’, and four commercial cultivars including: ‘Golden Delicious’, ‘Red Delicious’, ‘Braeburn’ and ‘Fuji’ was investigated. ‘Fuji’ had the highest amount of cyanidin 3-galactoside (3711.9 mg.g-1 fresh weight) and ‘Golab Kohanz’ had the greatest amount of quercetin 3-galactoside (3133.8 mg.g-1 fresh weight) and phloridzin in the skin (642.2 mg.g-1 fresh weight) and ‘Ghara Yapragh’ showed the greatest amount of flesh phloridzin (98.1 mg.g-1 fresh weight). ‘Abbasi Mashhad’ had the largest amount of flesh (484.3 mg.g-1 fresh weight) and the skin's (298.1 mg.g-1 fresh weight) chlorogenic acid, ‘Ghezel Alma’ had the greatest amount of catechin of skin (255.2 mg.g-1 fresh weight) and ‘Sib Torsh Dirras’ showed the highest catechin of flesh (76.9 mg.g-1 fresh weight). The regression analysis of total phenol and antioxidant capacity showed a positive correlation between the amount of total phenol and the antioxidant activity. The highest amount of total phenol and antioxidant activity in ‘Fuji’ was observed.