Introduction: Coronary artery disease is the most common cardiovascular disease that results in death, disability, and the imposition of many economic costs on the society and humans. The aim of this study was to determine the relationship of probability of coronary artery bypass graft based on perceived stress, spiritual intelligence, Islamic lifestyle and social support in patients referred to Vali-e-Asr Hospital of Qom. Methods: The study was descriptive-correlational and was performed on 122 patients (69 patients and 53 healthy individuals), who were voluntarily selected from Vali-e-Asr Hospital of Qom, and were diagnosed with obstruction or had no obstruction. Angiographic results were reviewed. In order to collect data, “ Perceived Stress Scale” , “ Multidimensional Scale of Perceived Social Support” , "Islamic Life Style Test", and "Integrated Spiritual Intelligence Scale" questionnaire were used. Data were analyzed using SPSS 22 software. Results: The results of the logistic regression analysis showed that with increasing the score of people in the variable of perceived social support and spirituality, the risk of coronary artery bypass graft decreased. By increasing the individual's score in perceived stress, the risk of coronary artery bypass graft increased (P < 0. 001). There was no significant correlation between lifestyle and the risk of coronary artery occlusion (P > 0. 001). Conclusions: There was a correlation between perceived stress, spiritual intelligence and social support and the probability of coronary artery bypass grafting. Therefore, it is suggested that patients with coronary artery bypass grafts participate in educational workshops to enhance spiritual intelligence and stress relief.