Observing hygiene behaviors in Islam is a desirable and important issue. The Holy Quran has pointed to it clearly and regarded it as its guidance and order. There are dozens of verses in the Holy Quran which discuss the hygiene and observation of hygiene, which is a part of growing-up and development; and on the other hand, there are important statement of the Prophet in the prophetic lifestyle which indicate his serious efforts in this regard. For instance, one can think of Religious leaders' lifestyle teachings and practical practices about the characteristics of each person and the maintenance of mental health in different age groups, which leads to safe growing-up and development. This descriptive-analytical article examines the methodology of religious education in three periods including adolescence, adulthood, and aging, and the way of treatment with each of these statistical populations has been examined by three examples of Prophet’ s speech style and behavior. In adolescence, the issues including, mood swings, spending time with others, and conflicts with others have been taken into consideration; in adulthood, issues including working life, mental health, positive attitude, and good performance; and at aging, issues including praying, respect for the elder and reform the attitude.