Background: The rise and fall of some hormones and accumulation of some disease markers in breast tissue, increases the breast cancer risk. Accumulating data suggest that exercise may affect breast cancer risk and outcomes. The aim of the present study was the effect of aerobic training on CA 15-3 tumor marker of breast cancer, growth hormone and insulin on breast cancer patients.Methods: 24 women breast cancer survivors with mean age 46.67 years in first and second stage of disease which did not use any special medicine, did not have any specific exercise, and underwent chemotherapy and radiotherapy selected and randomly assigned to exercise intervention (n=12) or group (n=12). Subjects of intervention group performed 8 weeks aerobic training with 50-70% Vo2max for 60 to 90 minute (3 sessions per). The control group did no exercise regularly. Before and after eight weeks, all subjects' blood samples were taken. The obtained data were analyzed using Dependent and independent T test.Findings: Results showed that aerobic training didn’t significant change in CA 15-3 (t=1.14, p=0.26), insulin (t=0.92, p=0.36) and growth hormone (t=0.30, p=0.76). There was not significant deference's showed between experimental and control groups in all variables (P³0.05).Conclusion: It appears that aerobic training can adjust some of the factors in recurrence breast cancer and reduce the risk of recurrent.