Introduction: Psychological factors in addition to various parts of the body, including the immune system, nervous system, endocrine system and digestive system play a major role in human health. According to the Quran, Hadith and Islamic guidelines, the special position of health in Islam can be realized. One of the sublime precepts of Islam is "fasting" which has a key role in individual and social growth and human progress such as prayer and other divine commandments.Islam has expressed fasting as an important factor for the health of body and soul, which has been mentioned directly in many verses of Quran and Islamic traditions.Nowadays, World Health Organization knows spirituality as a major aspect of health and emphasizes the importance of its impact on health more than ever before. This review article investigated the fasting impact as one of the Important and noble precepts of Islam on body and soul health of human and their relationships with the increase of immune system and thus the promotion of health, levels according to the Quran, Hadith, Islamic traditions and scientific and research findings and papers.Methods: The present review study investigated the relationship between fasting and the physical and spiritual health and its effect on the increase of health level based on Qur' an verses, religious traditions, religious books and resources as well as books and valid scientific-research papers have been used.Findings: The importance of fasting and its relationship with the health of body and soul are mentioned in many verses of Qur' an and authentic religious traditions and Hadith. The significance of fasting in the improvement of health and immune system has been emphasized in Altareq Sura -fourth verse- and scientific evidences, too.Conclusion: Spiritual benefits of fasting which are in connection with religious beliefs of the fast person is much more important than its physical effects on the human body and it can be said that the main purpose of fasting is spiritual benefits.Many studies show the spiritual and material effect of fasting on the promotion of the immune system. According to the World Health Organization's definition and considering spirituality as a fourth dimension of health, spiritual aspects of fasting and its relation with the increase of health level must be discussed further. In addition, scientific and educational centers must pay more attention to the importance of fasting from spiritual health perspective and its impact on enhancing the immune level of body.