Forty years since the establishment of the Islamic Republic of Iran, the concern of most elites, intellectuals, the people who care about the System and Revolution and especially that of the wise leader of Islamic Revolution is a comprehensive and wise struggle without tolerance against economical corruption. Aims of the Supreme leader as the fundamental theory is the focus of the present research, and the aim of this research is to identify the factors, importance, consequences and approaches to counter economic corruption, with emphasis on national security, and to achieve this goal, we used qualitative content analysis, and in organizing the analysis, we used the raw data for Inductive approach based on discussion, inference of concepts, issues and indices. Then, by discovery of fundamental meanings, inference, conceptualization, economical corruption issues and the components of national security within the goals and guidelines of The Supreme Leader, reasons, importance, consequences and approaches against economical corruption were identified. The results of this study confirm this point that, serious and fundamental confrontation against economic corruption in five dimensions results in upgrading security components, increased public and economic security of the community, improvements in performance, efficacy, system health, and Promotion and stabilization of the national security of the country.