The Purpose of this study was to determine the effect of aerobic exercise (60-70%) of maximal reserved heart rate) on LDL particle size, Apolipoprotein A-I (ApoA-1) and Apolipoprotein B (ApoB) as the most important cardiovascular effectors. METHOD: Twenty - three previously sedentary males were randomly allocated to either an exercise (N=12, mean age ± SEM = 39.17±6.29) group or a control (N=ll, mean age±SEM = 41.58±7.86) group. The training program of at least 30min-duration, at an consisted of 8WK running, three session. WK intensity producing %60-70 maximal-1 reserved heart rate. RESULTS: LDL particle size increased significantly in Experimental Group (Pre: 258.85±2.75, Post: 264, 0.5±3.59A). Pre- and post-training mean ApoA-1. Did not change significantly in the exercise group (Pre 165.46±38.53, Post 175.50±31.73) (PS≤0.35). On the other hand, control group subjects had reduced ApoA-l but not significantly (Pre 172.1±59.49, Post 145.61±23.08) (PS O.094). ApoB concentration was not reduced significantly in both groups (Exp: Pre 91.72±29. 74, Post 84.7±21.6; Control: Pre 104.21±17.84, Post ± 13.701). Comparison of post test ApoB/ApoA -1 results showed significant deferences between tow groups (Exp: 0.55, CONT: 0.72)(PSO.02). CONCLUSION: According to these results, ApoA-l &ApoB concentration did not change significantly, but 8 Wks aerobic training had beneficial and significant effects on LDL size and ApoB/ ApoA-l, so that CHD was reduced among exposubjects. Thus, middle aged males can use such an exercise training program in order to prevent cardiovascular diseases. However, mechanism of ApoA -1 & ApoB changes has to be investigated in future studies.