Hemorrhoidectomy may be associated with severe pain in the first 24-48 hours of operation. In order to access the analgesic effect of ischiorectal fossa block in hemorrhoidectomy, 24 patients (12 cases underwent ischiorectal fossa block and 12 cases in control group) were evaluated after the hemorrhoidectomy. The surgical and anesthetic technique were the same for two groups. The pain was scored by McGill Vzsual Analog Scale in 2,4,12 and 24 hours after operation by expert nurses, who were blinded to the technique of analgesia. The mean of pain scores of patients who underwent ischiorectal block were 1.25,1.41,2.66,2.83 and the scores in control group also were 2.83,3.83,4.08 and 3.91 (P<0.001). During the first 24 hours of operation, parenteral analgesics were used for 6 cases of group one, however all of patients of control group needed the analgesics. Therefore, ischiorectal block apparently decreases the pain of post hemorrhoidectomy and the need of parenteral analgesic administration.