The purpose of current research was studying and comparing of self-efficacy, and self-regulation among opioid substance, stimulant substance dependents, and general persons. Research design was non-experimental (causal comparative method). This research performed on 214 persons (106 general persons, 70 opioid substance dependents, and 38 stimulant substances dependents). Substance dependents were chosen from MMT centers. The self-efficacy questionnaire (Sherer et al, 1998) and The self-regulation questionnaire (SRQ; (Brown, Miller, & Lawendowski, 1999) were administrated for collecting data The results showed that there was a significant difference among opioid substance, stimulant substance dependents, and general persons in self-efficacy and self-regulation. Opioid substance dependents have less self-efficacy and self-regulation scores than General persons and stimulant substance dependents. In self-efficacy and self-regulation, there was not significant deference between stimulant substance dependents and general persons. Also, the results showed that there was a significant and positive relationship among self-esteem, selfefficacy, and self-regulation. So, we conclude that self-efficacy, and self-regulation has important role in preventing, coping, and substance abstinence.