The rise in the rate of addiction among women and the resulting increase in women’ s vulnerability has been a predominant debate in social pathology during the past few years in Iran. Accordingly, this study, with the guidance of the principles of the method of descriptive phenomenology, aims to analyze the addiction narrative as told by drug-addicted women. The data were collected using targeted sampling and deep and semi-structured interviews from women with a history of drug abuse residing in the city of Isfahan. According to the findings, the five themes of pleasure-seeking and pain-avoidance, a vulnerable character, weakness in life skills, an unsafe family, dominance of male norms and facilitating processes have been the most important reasons and motivations behind drug abuse among women, which have caused the formation of certain inner-personal and outer-social consequences for addicted women. The Necessity to leave, family’ s dual behavior, and the challenges around harm-reduction services have respectively been the most important challenges for women on their path to rehabilitation. In total, 11 third-level categories, 29second-level categories, and 413 semantic terms were discovered and extracted.