Objectives: The emergence of entrepreneurial university is the result of inner development of university, impact of external factors on university, and increasing importance of knowledge and innovation in society. This study aims to provid a model for development of entrepreneurial university ecosystem at state universities in Iran. Method: This was based on the sequential exploratory mixed method and in two sections of qualitative and quantitative. In qualitative section used grounded theory method and in quantitative approach researchers used correlational method based on PLS and structural equation modeling. The population consisted of policy makers and professors, managers of entrepreneurship centers, growth and science and technology parks, industry department authorities, and PhD candidates in Tehran, Beheshti and Tarbiat Modarres University. Using purposeful sampling method in qualitative section and in quantitative section was people based on multi-stage random cluster sampling. 20 people were selected as key informants. The data were collected through a and semi-structured interview and in quantitative was questionnaire based on item of qualitative section two methods including reviewing accountable validity and external and questionnaire through Cronbach's alpha (0. 83) used to obtain validity and reliability of data. Results: At axial coding stage, causal factorss, contextual, interventional, actions and interactions and outcomes were identified and presented in conceptual model. 72 indicators and 18 factors were approved using factor loading, extraction mean variance and high convergence validity (0. 4), z high coefficients (1. 96), coefficient of determination (R2) and goodness of fit (GoF= 0. 55). Conclusions: Universities need to develop an entrepreneurial ecosystem in which entrepreneurship flourishes. Entrepreneurship ecosystems are the result of interaction and commitment of the community and the university, roles, infrastructures and events that provide a suitable environment for the creation and development of levels of entrepreneurial activity.