Introduction: Affective capital is one of the decisive variables that can be effective in improving the conditions of female students with depression. This study aimed to determine the effect of positive mindfulness therapy, mindfulness-based cognitive therapy, and cognitive-behavioral therapy on affective capital in female students with depression. Methods: The research method was semi-experimental, and the research design was four groups with two stages (pre-test and post-test design). To carry out the research, from first secondary school female students with depression in Naein city in 2017, 60 female students were selected and randomly assigned into three therapeutic groups (each group with 15 people) and a control group (with 15 people). Affective capital questionnaire (ACQ-Golparvar, 2016) was used to measure the dependent variable in the pre-test and posttest. The group of positive mindfulness therapy, mindfulness-based cognitive therapy, and cognitivebehavioral therapy received 12 sessions of treatment. The data were analyzed with the use of multivariate analysis of covariance (MANCOVA). Results: The results showed that there is a significant difference between positive mindfulness therapy, mindfulness-based cognitive therapy and cognitive-behavioral therapy with control group in affective capital (F = 340. 40, P < 0. 001) and their components (positive affect (F = 292. 90, P < 0. 001), feeling of energy (F = 210. 91, P < 0. 001), and happiness (F = 186. 59, P <0. 001)) in post-test after controlling for pretest (P < 0. 001). Also, there is not a significant difference between positive mindfulness therapy and mindfulnessbased cognitive therapy in affective capital and their components, but there is a significant difference between positive mindfulness therapy with cognitive-behavioral therapy in total effective capital, positive affect, and feeling of energy. Conclusions: According to the results of this research, positive mindfulness therapy and then mindfulnessbased cognitive therapy and cognitive-behavioral therapy could be used to enhance the effective capital of female students with depression in educational and therapeutic settings.