ALBORZ UNIVERSITY MEDICAL JOURNAL
Year:2020 | Volume:9 | Issue:1|Papers Count:12

Background: Primidone is effective in the treatment of epilepsy. In this research, effect of primidone on levels of liver enzymes and liver tissue change in adult male rats was studied. Material and Methods: For this purpose, 40 adult male wistar rats, weighing approximately 180-200 g were divided into 5 groups of 8 animals. Groups: control group, Sham group and treatment at doses of 20, 40, 60 mg/kg, orally for 42 days (every other day) respectively. At the end of the experiment, body weight were measured in all groups and then the blood sample was taken from heart and serum levels of AST, ALT, ALP and GGT enzymes were measured. Furthermore, The pathological changes of the livers were studied after hematoxylin-eosin staining. The results were analyzed using ANOVA and Ttest statistical analysis. Results: the results show that body weight in experimental groups had not a significant difference compared to control group. Serum level in AST, ALT, ALP, GGT in experimental groups had a significant increase compared to control group (p≤ 0/05). In tissue samples in experimental groups which were provided a higher level of necrosis was observed. Conclusion: Primidone causes increase serum levels of AST, ALT, ALP, GGT and liver necrosis.

Introduction and Aim: The doctor-patient relationship is built largely on trust. It is in the shadow of trust that the patient can safely transfer all necessary information to the physician, which makes it possible to diagnose and treat medical treatment. The aim of the present study is to identify, prioritize and determine the causal relationships of factors affecting the patient's confidence in the physician. Methods: The present study is applied in terms of purpose, and is descriptive-survey in terms of data collection. The statistical population is the experts who were selected by snowball sampling method. The Dematel method is used to determine the relationships and the ANP method is used to prioritize the criteria. Results: The results of this study showed that in the main criteria of the factors related to the physician in his/ her self with a normal weight of 0. 422, has the highest priority and according to the sub criteria, the patient's knowledge of the skills and experience of a physician in the first priority has it. Also the factors related to the patient in his or he selfhave the most impact and the factors related to the patient on the other side has the most impact. Conclusion: The criteria of faith, duty, competence and mastery of the doctor, accountability and predictability of the physician, and the observance of ethics by the physician are factors that have the greatest impact on the patient's trust in the physician and the consideration of these factors can play an important role in promoting trust the patient to the doctor.

Background: Tranylcypromine is a monoamine oxidase inhibitor (MAOI)-it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxuolytic agent in the clinical treatment of mood and anciety disorders, respectively. In this research, the effects of Tranylcypromine the serum concentrations of LH, FSH and Testosterone as well as changes in body weight and testicular tissue were studied in rats. Material and Methods: 50 adult male Wistar rats with approximate weight of 200-250 gr were divided into 5 groups of 10 animals: the control, sham group and three experimental groups receiving 40, 20 and 10 mg/ kg Tranylcypromine, respectively. The drug was orally administered for 21 days. Following wighting at the end of this period, blood samples were taken from each rats, centrifuged to obtain serum, and testis were removed, weighted and fixed to examine their possible histological changes. Serum samples were frozen at-20 to be studied later. The serum cocentrations of LH, FSH and testosterone were measured by RIA. After tissue sectioning and staining with hematoxylin-eosin, testicular tissues were examined by light microscope. The SPSS and Excel software and ANOVA and Tukey tests were used for statistic analyze. Results: The results showed that 21 days consumption of maximum doses of Tranylcypromine, significantly increases concentrations of LH and FSH hormones and significantly reduce testosterone concentration in maximum doses and leydig cells in all three experimental groups (P≤ 0. 05). In addition, no significant effect was observed in the body weight, testicular weight as well as Sertoli cells. Moreover, testicular tissue study indicates that 21 days of Tranylcypromine consumption significantly reduces spermatogony, spermatid, spermatocyte and thus, affects spermatogenesis. Conclusion: Tranylcypromine drug reduced levels of testosterone and increase levels of LH and FSH hormones.

Background: Periodontal diseases in smokers are 2. 6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is effective. Regarding the importance of free radicals in the pathogenesis of periodontal diseases, the aim of this study was to investigate the effect of cigarette on the oxidative and antioxidant status of saliva in chronic periodontitis patients and compare it with healthy controls. Methods: In this case-control study, 20 patients with chronic cigarette smoking periodontitis, 20 patients with non-smoking chronic periodontitis and 20 healthy individuals who had no history of periodontitis and smoking, were among those referring to dental clinics and clinics of Karaj were chosen. Uninstivated saliva was collected and salivary total antioxidant capacity was measured using a kit in saliva. Statistical analysis was performed using ANOVA. Results: Total antioxidant capacity of saliva in smoker periodontitis and non-smoker periodontitis was significantly (P <0. 05) less than normal Persons. Conclusion: Based on the results of this study, chronic periodontitis reduces the total antioxidant capacity of saliva, on the one hand, due to the increased production of oxidants in inflammatory responses to this disease, and, on the other hand, the presence of compounds such as nicotine cigarette that disturbs the chain Respiratory mitochondria and increased oxidants.

Background: Hematological disorders such as increased white blood cells and platelets (elevated white blood cell and platelets) in coronary heart disease (CHD) are associated with increased mortality. Exercise could specifically influence hematologic factors. The purpose of this study was to survey the response of hematological factors to home-based exercise rehabilitation and center-based cardiac rehabilitation in coronary artery disease. Methods: This semi-experimental study was conducted on 40 patients (mean age, 59 ± 6. 28 years) in Isfahan cardiovascular research center. The participants were voluntarily divided into 3 groups: home-based exercise rehabilitation (n=13), centre-based CR(n=15) and control(n=12). white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV) and Platelets (PLT) were measured at baseline and after 2 months of CR. Data were analyzed using analysis of one-way ANOVA in P<0. 05 level. Results: After 2 months of CR, MCH and MCHC in the home-based exercise rehabilitation group and Hb, Hct and MCV in the centre-based CR group increased significantly. In home-based exercise rehabilitation group, RBC, PLT and Hb associated with a significant decrease. Conclusion: the regular, moderate-intensity physical activity in both groups of cardiac rehabilitation led to relatively improvement some of the hematological factors.

Preventing and reducing the spread of HIV (HIV) has always been a concern in medical science. One of the most common ways to control the virus is using enzyme-blocking drugs. In this study, we attempted to predict the biological activity (PKi) of organic urea derivatives in protease inhibitor compounds using molecular modeling using QSAR (Quantitative Structure Activity Relation), which is the basis of quantitative study of the structure between And there is activity. Models were presented. In this study, the chemical structure of 41 compounds was optimized by Gaussian 09 software and other properties (descriptors) were obtained using software. The level used in B3LYP calculations and ground state series was 6-31G *. Validation tests were then performed on the obtained models. The results of the statistical data were acceptable. Given the effective variables in the models, it predicts biological activity and invokes appropriate drug design.

Introduction: Bioaccumulation Capacity of Heavy metals in aquatic bodies can do a serious threat to food security and public health. Therefore, in this study, the amount of lead, cadmium and copper in edible tissues of hydrothermal fish in Alborz province was determined in 2017. Materials and Methods: Twenty-one carp fish of three species were randomly selected from the Mahmoudi fishery, which supplies the Alborz hydrothermal fish market, and after acidic digestion of the specimens, the concentration of lead, cadmium and copper was determined by Atomic absorption device. Results: The mean concentration of lead, cadmium and copper in wild carp, amur and phytophagus in ppb and for cadmium was measured.   Highest amount of lead in Hypophthalmichthys molitrix,   Cadmium in Ctenopharyngodon idella &Copper in Hypophthalmichthys molitrix was observed. Statistical comparison of the mean concentrations of the Heavy metals with the guidelines of the United Nations Food and Agriculture Organization showed that the mean concentration of all Heavy metals was lower than the permissible limit. Discussion: Although currently the mean concentrations of the evaluated Heavy metals in the carp edible tissue of Alborz province are not exceeded, but lack of proper management of the water supply resources of fish ponds can lead to the entry of pollutants, including heavy metals, into the fish farm. In resident aquaculture tissues, endangering the health of consumers.

Introduction: Chlamydia trachomatis is one of the most prevalent causative agents of sexually transmitted diseases which is related to a wide range spectrum of diseases such as cervicitis. Regarding the prevalence of this bacterium and its known complications and it was unclear prevalence in the Karaj region; therefore this study was conducted to determine the demographic status C. trachomatis in women cervicitis referred to Kamali hospital. Methods: In this cross-sectional study, out of 167, 100 women with cervicitis symptoms (according to gynecologist's diagnosis) were examined by PCR method for C. trachomatis. The data of each patient were entered into the questionnaire and the results of questioner were analyzed by SPSS software version 16. Results: Out of 100 samples, 55 (55%) samples were C. trachomatis positive. The results of this study showed that among the variables studied there is a significant relationship between erythema and C. trachomatis infection. Conclusion: The analysis of questionnaire result showed that, the most positive cases were among patient with non-academic, married, housekeepers. In spited of the results of most research carried out in other countries, the rate of infection in housewives without multi partner was higher than the other groups. The results of the study are noteworthy and need a broader precisely studies in the future and emphasize the sexual health education and encouraging screening program in Iran.

Background: Diabetes mellitus is one of the leading causes of death in the world as a result of a defect in the secretion or function of insulin. Sometimes insomnia can be a complication of diabetes or it can be a factor in diabetes. On the other hand, impairment in sleep quality is associated with increased risk of diabetes and mortality. Some studies have also shown that sleep deprivation has different effects on athletic performance. The purpose of this study was to investigate the effect of sleep disorders on cardiovascular and exercise performance in diabetic patients. Materials and Methods: The present study was a quasi-experimental and included 25 diabetic patients selected according to the study conditions. Tests for measuring anaerobic power (Wingate test), blood pressure, heart rate, and blood glucose levels were performed in four weeks. Data were analyzed by repeated measures of variance analysis and Bonferron's post hoc test. Results: Insomnia caused a significant increase in blood glucose, heart rate and anaerobic power (P<0. 05), but there was no significant effect on the blood pressure (P>0. 05). Conclusion: Since sleep deprivation can increase the risk of complications of diabetes, improving the sleep patterns of people with diabetes should be considered.

Background and Aim: Removal of permanent teeth is one of the outsourced dental practices in dental clinics. Statistics and reasons can be fluctuated due to societal changes at the community level, such as the economic category and the level of social and cultural empowerment of individuals, the phenomenon of aging, or any change in the age-old population of the population. The aim of this study was to determine the relationship between the frequency and etiology of tooth extraction with demographic factors and the health status of patients referred to the Faculty of Dentistry. Materials and Methods: This cross-sectional study was conducted in spring of 2016 from 200 patients referred to Shahed University of Dentistry. Data were collected through a demographic questionnaire and a dental exam form. Data were analyzed using SPSS 21 software using ANOVA and T-test. Findings: In this study were 59% of causes of caries tooth extraction, 21. 9% periodontal and 22. 4% of prosthodontics. There was a significant difference between educational level and tooth extraction due to periodontal and paradoxical causes and the status of employment and tooth extraction due to periodontal disease and economic status with periodontal and prosthodontics causes, paradigm and orthodontic findings. There was no significant difference between the causes of tooth extraction between single and married patients (p> 0. 05). There was a significant difference between the causes of caries, periodontal, impaction and orthodontic according to the condition of oral hygiene (p <0. 05). Conclusion: Considering that decay is still one of the most common causes of tooth extraction, it is recommended that measures be taken to prevent dental caries. On the other hand, most people with a degree have a diploma and a diploma. Also, 80. 8% of people are poorly and moderately in terms of their economic situation. Therefore, there is a pressing need to increase the level of awareness of the community and, in addition, to increase the service to the weak community of society.

Introduction: Myopathy and rhabdomyolysis are not common in children and, if not detected and do not treated it will be associated with high mortality and morbidity rate. The causes of rhabdomyolysis include hypokalemia, trauma, viral myositis, poisoning, rheumatoid diseases, and metabolic myopathies. Rhabdomyolysis treatment includes rapid supportive care and treatment of the underlying disease leading to rhabdomyolysis. Case Presentation: 10-year-old girl with progressive muscle weakness was admitted in Pediatric Intensive Care Unit (PICU) with acute renal failure and respiratory failure. The laboratory results showed myoglobinuria, high CPK, LDH. The initial diagnosis was severe rhabdomyolysis. In addition to fluid therapy and diuretic, she was treated with carnitine and riboflavin with possible glutaric aciduria type II. The patient showed progressive improvement after a few days. Result of plasma acyl carnitine and urine organic acid analysis stablished the diagnosis of glutaric aciduria type II. Conclusion Late onset glutaric aciduria type II has been described as a rare but treatable cause of myopathy and rhabdomyolysis. Glutaric aciduria type II is an important differential diagnosis to consider in children and adults presenting with myopathy and rhabdomyolysis.

Background: Diabetes Mellitus (DM) is considered as one of the most frequent chronic disease, which have numerous physical effects and a varity of manifestation in oral region but limited and contaversied research done in this field. Thus, this study was aimed to determine the comparison of oral manifestation frequency in diabetic patients and nondiabetic persons. Methods: In this cross-sectional Study, after obtaining consent form, 140 diabetic patients which refered to Hamedan diabetic research center and 140 non-diabetic (control subjects), were evaluated. Oral lesions (White plaque, Erythematous lesions, white and red lesions, Median Rhamboid Glossitis, Geographic tongue, Xrestomia, angular cheilitis, Trush) were diagnosed besed on clinical creteria. Data regarding oral lesions were recorded and analyzed by Chi Squaire, Fischer and T-test. Results: Prevalence of oral lesions doesn’ t show significantl relation with sex and location. Xrestomia, white and red lesions and Geographic tongue were manifestaed significantly greater in DM patients. Only trush lesions had related with longer duration of diabete. (p=0. 024) Conclusions: prevalence of oral lesions was significantly higher in diabetic patients than controlled group. Close collaboration between the patient and health care team to rapid diagnosis of oral lesions could lead to promotion of the patient’ s oral health and quality of life and also a decrese in the burden of disease.