Iran's eastern border regions, having long borders with Afghanistan and Pakistan, and because it is the shortest, most economical and most important international transit route from East to West, are one of the most vulnerable areas in the fight against drug trafficking. Geomorphological factors such as connecting eastern provinces with Lout Plain, poor economic conditions of border areas such as high unemployment rate and extreme poverty and deprivation, the extent and variety of eastern border geographical environment, lack of border control equipment, and overcoming security approach to border management have provided the most important ground of drug trafficking into Iran. The purpose of this study was to investigate the challenges and capacities of the border regions of the country in the fight against drug abuse through a semi-structured interview. Seventy people were interviewed in the three groups of frontiersmen, traffickers, border officers and experts. The findings show that the challenge of the borders and eastern regions of the country in relation to drug trafficking is primarily economic and widespread poverty and unemployment and secondarily political, social and natural factors. Also the economic capacities of the eastern borders of the border markets, foreign trade, tourism, agriculture and mines are important. Therefore, instead of ruling out the security and law enforcement approach, it is suggested to replace the development-oriented approach in the eastern part of the country to reduce the growth rate of trafficking while activating the economic potential of the region.