In this research, the inflation rate, liquidity, bank interest rate, and exchange rate (the replacement for the dollar) are considered as economic variables. In addition, their impact on the structure of capital, which is the ratio of debt in companies, has been investigated. The method and nature of the present research is a correlational research and a combination of data approach was used for analyzing research data and estimating models. The study results indicate that three variables of inflation rate, exchange rate, and liquidity volume have a significant effect on capital structure, but interest rate does not have a significant effect on capital structure. Thus, changes in interest rates do not affect the debt ratio and the other two variables; inflation rate and the volume of liquidity have a negative effect on the capital structure. Hence, financial managers will pay special attention to the effects of changes in the inflation rate on the capital structure and the positive effects of the exchange rate when deciding the financials, combining the required cash resources, and studying the changing process made by these variables.