Introduction: Optimal academic performance is the foundation of success in the student's future life. Successful academic performance of students leads to the growth and excellence of society in various fields. The aim of this study was to investigate the effect of maternal general health, attention deficit hyperactivity disorder and self-esteem on the child’ s academic performance. Methods: The research method in this study was correlational. The statistical population included all male and female primary school students in Behbahan in the academic year 2016-2017. In the present study, the sample size of the subjects was 370 based on Krejcie and Morgan table. The sample was selected by two-stage cluster random sampling. The research instruments were Dortaj (2014) Academic Performance Scales, Connors-Form Parent, Goldberg General Health and Cooper-Smith Self-Esteem. Result: Findings of Pearson correlation coefficient test revealed that there was a significant relationship between child academic performance and maternal general health (r=-0. 47, p<0. 001), attention deficit hyperactivity disorder scores (r=-0. 53, p<0. 001), and child self-esteem (r=-0. 3, p<0. 001). Findings of multiple regression analysis also showed that maternal general health scores (β =-0. 21, p<0. 001), attention deficit hyperactivity disorder (β =-0. 38, p<0. 001), and children's self-esteem (β =-0. 12, p<0. 02), were able to predict children's academic performance. Conclusions: Maternal general health status, scores of Attention Deficit Hyperactivity Disorder as well as the child's self-esteem can affect children's academic performance.