Hormozgan Medical Journal
Year:2011 | Volume:15 | Issue:1|Papers Count:12

Introduction: Hearing loss is the most frequent sensory disorder occurs in 1/1000 newborns. About 50% of hearing loss cases are due to genetic causes. Mutation in MTRNR1(A1555G), MTTL1(A3243G) and MTTS1(A7445G) are known to be one of the important cause of nonsyndromic Sensorineural hearing loos in some populations. This study aims to demonstrate the frequency of three mitochondrial mutations including A1555G, A7445G and A3243G in deaf subjects in Hormozgan province. Methods: We investigated the presence of three mitochondrial mutations including A1555G، A3243G and A7445G in a cohort of 110 nonsyndromic Sensorineural hearing loss subjects. DNA was extracted using standard phenol – chloroform method. The screening of gene mutations was performed by PCR-RFLP procedure. Finally, the possible mutations were confirmed by direct sequencing.Results: None of the 110 subjects were found to carry A1555G, A3243G and A7445G mutations. However, PCR-RFLP of the MTTL1 gene destroyed a restriction site due to G3316A substitution in a deaf subject.Conclusion: We found that the association of A1555G، A3243G and A7445G mutations with hearing loss in Hormozgan is negligible.

Introduction: The cutaneous leishmaniasis has been regularly spread in Iran. Jask County, which has been located in the eastern part of Hormozgan province, had the most cases of patients. The present study aimed to investigate on the fauna and biology of sand flies. Methods: In this descriptive, cross sectional study, during 2007-2008, sand flies were captured using sticky papers and CDC miniature light traps. Flies species were identified using microscopic method. Parity rate was examined by dissection to cheqeur accessory glands for pigments. The ELISA method was used for detection of anthropophagic index. Results: A total of 8123 sand flies were caught, so as 57.52% were male and 42.49% female (39.07% and 60.93% were caught indoor and outdoor, respectively). The fauna was identified 8 species (2 Phlebotomus and 6 Sergentomyia). Phlebotomus major was reported for the first time in Hormozgan province. P. papatasi and P. salehi were the dominant species. Monthly activity of sand flies begins at the end of Esfand, lasting to mid Azar with two peaks, the first in Ordibehesht – Khordad and the second one in Mehr-Aban. The parous rate was high (³70%) at the second peak. The dominant species showed high anthropophagic index (29.6% and 18%, respectively).Conclusion: Although the sand flies fauna is poor in Jask County but they are highly diverse. P. papatasi and P. salehi transmit the Leishmania parasite from reservoir rodents to human. According to the endophility, residual spraying twice a year (Esfand and Shahrivar) could be effective in hyperendemic villages.

Introduction: Inhaled corticosteroids are recognized as the most effective anti-inflammatory therapy in patient with asthma. Further studies must be done about potential adverse effects of inhaled corticosteroid on linear growth in asthmatic children. This study aims to assess the effects of treatment with Inhaled corticosteroids on linear growth in 6-12 years old asthmatic children.Methods: In a randomized clinical trial study, we randomly selected 70, 6-12 years old, asthmatic children as cases and 70 healthy children as control group. The asthmatic children were classified into two groups, one group included 35 asthmatic patients on beclomethasone 450 microgram per day and another group included 35 asthmatic patients on fluticasone 250 microgram per day. Height of all children was measured with tandard stadiometery in first visit, six month and one year later. The data were analyzed using t, Chi- Square and analysis of variance tests.Results: There were 106 boys (75.7%) and 34 girls (24.3%). mean age was 7.35±1.09 without any significant difference between three groups. There was no significant difference in sex and duration of ICSs consumption among the groups. Mean of height growth, 6 month after ICSs prescription was 3.26 cm in beclomethasone group, 2.9cm in fluticasone group and 3.01 cm in control group. Mean of height growth one year after ICSs prescription was 6.21 cm in beclomethasone, 6.07 cm in fluticasone group and 5.92 cm in control group. The differences were not statistically significant.Conclusion: We observed no significant negative effect of usage of Inhaled corticosteroids (Beclomethasone 450 microgram per day and fluticasone 250 microgram per day) for 3 to 6 months on linear growth of asthmatic children.

Introduction: During spinal anesthesia, measurement of blood pressure is often obtained by an indirect method using an inflatable cuff on the upper arm. The relationship between the blood pressure measurements at the two sites in patients undergoing spinal anesthesia is unclear. This study was designed to evaluate the difference observed in systolic blood pressure (SBP) taken from the upper limb (UL) and the lower limb (LL) in patients under spinal anesthesia in lower abdomen surgery.Methods: In this descriptive-analytic study, 62 males undergoing lower abdomen surgery were selected. The blood pressure cuff was placed on the right arm, the right leg, the left arm and the left leg, respectively. Before and then 10 and 25 minutes after spinal anesthesia, the systolic blood pressure (SBP) readings was taken by finger palpation from the 4 limbs using the manual mercury sphygmomanometer. The data were analyzed using paired t-test and ANOVA.Results: We found that SBP reading taken from the legs before and 10 minutes after spinal anesthesia were significantly higher than arms pressures (P<0.001). The SBP in the legs in 25 minutes after spinal anesthesia showed more decline compared with the arms. There was no significant difference in SBP between upper and lower limbs in all the times.Conclusion: The blood pressure of the lower limb was higher than the upper limb. In cases that could not be detect the blood pressure from upper limb, we can measure it from lower limb. It is recommended to take a single blood pressure reading of arm before anesthesia and then use the lower limb for evaluating the difference between the two sites.

Introduction: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients.Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients.Results: 227 patients (9.7%) were male and 2052 (90.3%) patients were female. A higher frequency of discoid rash and urine casts and a lower frequency of arthritis and leucopenia were demonstrated in our male patients (P<0.05). The main features were not significantly alike.Conclusion: Incidence of coetaneous manifestation and lower incidence of arthritis in men as well as higher frequency of vital organ involvement such as kidney disease in male patients should be considered in clinical judgment and treatment planning.

Introduction: Satisfaction in life arises from mutual interests, acceptance, understanding and meeting the needs. The aim of the present study is to measure the efficiency of teaching communicative pattern of pluralistic family on life satisfaction of couples.Methods: The study was designed including pre-test and posttest with control group. The research population were all patients referred to the counseling centers of Shiraz city. 40 couples were randomly selected according to the revised version of family communication patterns of Koerner and Fitzpatrick. Diner test of satisfaction was administered on 40 couples and then randomly divided to control and experimental groups. 90 – Minute training in ten sessions were held for experimental group exposing them pluralistic communication patterns. Satisfaction test was repeated again for both groups. Data was analyzed with covariance analysis method using SPSS 15.Results: The results of the present study showed that with regard to life satisfaction , there was a significant difference in both groups (P<0.0001). The difference was also significant existed between the pretest and post test scores in both groups (P<0.001).Conclusion: Based on the findings, listening to and speaking with each other play a key role in life satisfaction, therefore, pluralistic communication methods based on high levels of listing – speaking interactions could be effective.

Introduction: Quality of life in patients with chronic diseases and its evaluation is important for suitable intervention actions. This study is designed to evaluate and compare quality of life in patients with and without fatique.Methods: This is an analytic study. 108 referential patients with Parkinson's disease in Shiraz Motahari clinic, participated in this study. Fatigue was measured by fatigue severity Scale (FSS), quality of life by the PDQL and (SF-36) tools. Hohen & Yahr index for assessing the severity and stage of disease were used. SPSS software and Chi square, t test, Mann-Whitney and Spearman correlation coefficient analyzed data.Results: 67 (62%) of the patient were men and 41 (38%) women. Most of the patients (38.9%) were in the second stage and Mean±SD age of the patients was 64/49 ± 11/73. 36 (33/33%) persons had symptoms of fatigue, 72 (66.66%) had no symptoms of fatigue. Patients with higher severity of fatigue were more suffering from disease and stage of their disease was higher. Quality of life score obtained with both PDQL and SF-36 had significance difference in both groups of the patients (P<0.05). Quality of life and fatigue showed a significant inverse correlation in all dimensions of the two questionnaires (P<0.05). Conclusion: The results showed that quality of life in patients with symptoms of fatigue is significantly lower than patients without symptoms of fatigue. More effort is necessary to improve quality of life of these patients.

Introduction: Osteoporosis is a multifactorial disease that leads to etiology leading to morbidity and economical disturbances. This study designed to evaluate the prevalence of osteoporosis in patients referred to Gorgan’s densitometry centers with respect to age, gender and BMI.Methods: In this descriptive-analytic study, from 3000 subjects referred to the densitometry centers of Gorgan, 300 subjects were selected via a random sampling method. Individual characteristics and densitometry results were collected from densitometry records. Data were analyzed by SPSS and chi square test and linear regression.Results: The overall prevalence rate of osteoporosis was 33.7% and 16.7% according to lumbar and femoral region, respectively. Lumbar and femoral BMD mean were 0.92±0.19 and 0.77±0.167, respectively. Association between age and osteoporosis in lumbar region (P-value<0.01, B:-0.322), in femoral region (P- value<0.01, B: -0.421) and BMI with osteoporosis in lumbar (P- value<0.01, B: 0.314) was significant but relation between BMI with osteoporosis in femoral region and sex with osteoporosis in femoral and lumbar region was not significant.Conclusion: Our findings revealed a higher prevalence rate of osteoporosis in patients referred to Gorgan’s densitometry centers and showed that age in femoral and lumbar region and BMI in lumbar region can regress BMD.

Introduction: Chediak-Higashi syndrome is a rare autosomal recessive disorder that characterized by severe immunodeficiency. It is also associated with a lymphoproliferative disorder termed the accelerated phase with lymphocytic infiltration of the major organ of the body.Case Report: The patients was a 1-year old boy with intermittent fever, anorexia, malaise. On physical examination he showed grey hair colour, tonsilar erythema and exudate and splenomegaly. Pancytopenia was detected. In bone marrow aspiration and hair microscopy remarkable intracytoplasmic pigmented granules was seen.Conclusion: It should be noted when pancytopenia, organomegaly and light hair colour are present an early bone marrow transplantation should be considered if the diagnosis is stablished.

Introduction: Multiple coronary artery aneurysm is a rare anomaly which could be congenital or acquired. Its complications including sudden cardiac death, clot and distal emboli, rupture and bleeding or fistula. Decision about its management depends on aneurysm conditions and the Patient's clinical situation.Case Report: A 55 years old patient with unstable angina and multiple coronary artery aneurysms and three vessels disease on angiography, underwent CABG. The patient was asymptomatic and showed normal activity after about two years of follow up.Conclusion: Here, multiple coronary artery aneurysms and its management is discussed as a rare disease.