Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Title: 
Author(s): 

Issue Info: 
  • Year: 

    0
  • Volume: 

    23
  • Issue: 

    3 (مسلسل 95)
  • Pages: 

    -
Measures: 
  • Citations: 

    0
  • Views: 

    651
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title: 
Author(s): 

Issue Info: 
  • Year: 

    0
  • Volume: 

    23
  • Issue: 

    3 (مسلسل 95)
  • Pages: 

    -
Measures: 
  • Citations: 

    0
  • Views: 

    815
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    1-9
Measures: 
  • Citations: 

    0
  • Views: 

    664
  • Downloads: 

    0
Abstract: 

Background and Aim: Atherosclerosis is known as a multifactorial inflammatory disease. Trimethylamine N-oxide (TMAO) as a risk factor, has a potential to trigger or enhance the immune inflammatory reactions in atherosclerosis. Yet, The exact mechanism by which TMAO induces inflammation during atherosclerosis is not well understood. The present study was designed to evaluate the expression of IL-1b, IL-6, and TNF-a mRNA in response to treatment of macrophages with different concentrations of TMAO.Material and Methods: In this experimental in-vitro study, U937-derived macrophages were treated with different concentrations of TMAO (37.5, 75, 150 and 300 mM) for 24 h. A group of cells were also treated with tunicamycin as positive control for stress. RT-qPCR was used to evaluate the expression of IL-1b, IL-6, and TNF-a mRNA levels. One-Way ANOVA and Post-hoc Dunnett test were used to compare the mean value of every group with that of control group.Results: Although TMAO increased expression of IL-1b, IL-6, and TNF-α mRNA, only 300 mM of TMAO significantly increased expression of IL-1b mRNA compared to the control cells (P<0.001). Tunicamycin increased expression of IL-6 significantly.Conclusion: The results of this study showed that among the above mentioned cytokines, IL- 1b as a proinflammatory cytokine had a greater role in inflammatory reactions, induced by TMAO as a risk factor for atherosclerosis.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    10-18
Measures: 
  • Citations: 

    0
  • Views: 

    714
  • Downloads: 

    0
Abstract: 

Background and Aim: Considering the increasing trend of thyroid cancer and increased number of new cases we performed this study to determine the risk factors for thyroid cancer in Kurdistan Province.Materials and Methods: 80 patients and 80 controls were matched and entered into this case-control study from September 2009 to September 2016 in Kurdistan Province. Data were collected by reviewing the records of the patients, making phone calls and face-to-face interviews. Using SPSS v.20 software, data analysis was performed by chi-square test, T-test and logistic regression.Results: The results showed that there were no significant differences between the two groups in terms of gender, marital status, residential place, and profession. Thyroid cancer showed significant relationships with obesity, history of thyroid cancer in family, use of levothyroxine and TSH level.Conclusion: The results of the study highlighted the importance of TSH level, obesity, history of thyroid cancer in family, and use of levothyroxine which can be considered as risk factors for thyroid cancer by education and health planners.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    19-25
Measures: 
  • Citations: 

    0
  • Views: 

    468
  • Downloads: 

    0
Abstract: 

Background and Aim: There are several reports about analgesic, anti-depressant, antiinflammatory, antiseptic, sedative, and anti-spasmodic effects of Jasminum sambac. The aim of this study was to investigate the analgesic effects of Jasminum sambac hydroalcoholic extract and determine the role of GABAergic and opioidergic pathways in rat model by a plantar device.Material and Methods: Wistar male rats were randomly divided into six groups (n=6) including control, the groups treated with hydroalcoholic extract of Jasminum Sambac (100, 200, 400, mg/kg, ip) and the groups which received the most effective dose of the extract in addition to naloxone or flumazenil. The analgesic effect was assessed by plantar device after 30, 60 and 90 min of the injections.Results: Our results showed that injection of hydroalcoholic extract of Jasminum sambac (200 mg/kg, ip) increased significantly the time delay in response to thermal pain inducing effect at 30, 60 and 90 (P<0.05) min after injection in the experimental groups compared to that in the control group. While, addition of naloxone, prevented analgesic effect of the extract at all three times (P<0.05). This pattern of reduction of extract analgesic effect was significant only 60 min after concomitant administration of the extract with flumazenil.Conclusion: The results indicated the analgesic effect of Jasminumsambac extract. Considering the preventive effect of naloxone on the analgesia produced by Jasminum sambac, opioidergic pathway seems to be dominant in the development of Jasminum sambac analgesic effect.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    26-35
Measures: 
  • Citations: 

    0
  • Views: 

    608
  • Downloads: 

    0
Abstract: 

Background and Aim: Recently, several studies have indicated that the central nervous system has the capacity for endogenous repair. But, the proliferation capacity of endogenous neural stem cells (NSCs) isn’t sufficient for the treatment of neurodegenerative diseases. So, it sounds that stimulation of endogenous NSC proliferation is essential for neuroregeneration. The aim of this study was to examine the effects of Sambucus ebulus extract on the proliferation of neonatal rat hippocampus-derived neural stem cells (NSCs) under oxidative stress condition induced by H2O2.Material and Methods: The NSCs were isolated from neonatal rat hippocampus. To confirm neural characteristics of neural stem cells, the expression of neural-specific marker, Nestin was investigated by immunocytochemistry technique. 5×104 cells were cultured in every well of a 96 well plate and H2O2 was added to induce oxidative stress condition. Then NSCs were exposed to 50 μg Sambucus ebulus extract for 24 hours, at various concentrations (25, 50, 100, 200, 400 and 500 mg/ml). The cell proliferation rate was assessed by MTT colorimetry assay before and after treatment with the extract.Results: Immunofluorescent studies showed that neural stem cells expressed specific neural marker; Nestin. The proliferation rate of NSCs increased in the treated groups in comparison to that in the control group. The highest rate of survival was observed when Sambucus ebulus was used at the concentration of 500 mg/ml. (P<0.05).Conclusion: The results showed that the methanolic extract of Sambucus ebulus can promote proliferation and survival of NCSs in vitro and also after exposure to oxidative stress condition, suggesting its potential beneficial effect on neuroregeneration.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    36-44
Measures: 
  • Citations: 

    0
  • Views: 

    820
  • Downloads: 

    0
Abstract: 

Background and Aim: The frequent use of opioids changes function and plasticity of neural circuits. Exposing the immature nervous system to opioids can have deeper and more extensive impacts. The aim of this study was to investigate the effects of morphine consumption during lactation period on learning and memory of rats offspring.Material and Methods: This experimental study included 40 male Wistar rats with age range of 45-50 days. Animals were divided into control group (CO) and 3 experimental groups of rats whose mothers had received subcutaneous injections of 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during lactation period. Spatial learning was evaluated by Morris water maze (MWM) on 4 consecutive days (4 trials/day). Spatial memory retrieval was also evaluated on the last day.Results: Our results indicated that the rats whose mothers had received morphine during lactation period spent more time and traveled more distance to find the hidden platform than the controls in the learning stage. These differences were statistically significant when doses of 10 and 20 mg/kg morphine (P<0.001) were used. Also, they spent less time and passed less distance in the target quadrant in probe trial (P<0.001).Conclusion: Morphine consumption during lactation period impairs spatial learning and memory of the rats' offspring in a dose dependent manner.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Author(s): 

AMIRI H. | FAKOUR SH. | AKRADI L.

Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    45-55
Measures: 
  • Citations: 

    0
  • Views: 

    579
  • Downloads: 

    0
Abstract: 

Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is recognized as a metabolic liver disease in the world. The purpose of this study was to investigate the preventive effects of Punica granatum extract on fatty liver disease in the rats receiving high fat diet.Material and Methods: In this study rats were divided into 6 groups: healthy control, feeding with high fat diet, feeding with high fat diet plus clofibrate and feeding with high fat diet plus Punica granatum extract with different doses for 6 weeks. At the end of the experiment biochemical indices including LDL, HDL, triglyceride and cholesterol, hepatic enzymes (AST, ALT, ALP) and concentrations of GPX, SOD, and CAT antioxidants in serum were measured. After histopathologic examinations and grading of fatty liver the groups were compared with one another.Results: High-fat diet group showed statistically significant increase in hepatic enzymes, cholesterol, triglyceride and LDL compared to other groups. Whereas high dose extract and clofibrate groups showed statistically significant increase in HDL and antioxidant activity compared to other groups. The results of histopathological examination showed fatty liver changes of grade 4 in the high-fat diet, grade 1 in the extract and grade zero in the clofibrate groups.Conclusion: The results of this study showed the preventive effect of Kurdistan native Punica on fatty liver disease which is related to its antioxidant properties.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    56-66
Measures: 
  • Citations: 

    1
  • Views: 

    1154
  • Downloads: 

    0
Abstract: 

Background and Aim: Reduction in sperm motility is one of the main causes of male infertility. The aim of this study was to investigate the effect of Carob supplementation on sperm parameters, inflammatory factors, oxidative stress indices and sex hormones in the men with idiopathic infertility.Materials and Methods: This study was a randomized double-blind controlled clinical trial which included 60 men with asthenospermia. The patients were assigned to intervention and placebo groups (n=30). The intervention group received 1500 mg Carob / day (three 500 mg capsules), and the placebo group received three placebo capsules / day for 12 weeks. The parameters of sperm, total antioxidant capacity, malondialdehyde concentration, inflammatory markers and plasma sex hormones were measured at the beginning and at the end of the study. Statistical analysis was performed by SPSS software and independent sample t-test was used to compare the mean values of changes between the two groups. P-value of less than 0.05 was considered statistically significant.Results: Differences in the changes in number, concentration and the percentage of motile sperms, total antioxidant capacity, concentration of MDA and plasma inflammatory markers were significant after the intervention (p<0.05). Changes in sex hormones were not significant in the two groups (P>0.05).Conclusion: Increased concentration and motility of the sperm and decreased oxidative stress and inflammatory factors were observed in the intervention group. Use of plants with antioxidant capacity can be one of the ways to cope with oxidative damage to sperm in this group of infertile men.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    67-72
Measures: 
  • Citations: 

    0
  • Views: 

    621
  • Downloads: 

    0
Abstract: 

Background and Aim: In recent decades, the emergence of resistant strains of staphylococcus aureus, pneumococci, enterococcus and intestinal gram-negative bacteria due to the inappropriate use of antibiotics has emphasized the necessity of proper use of antibiotics. The aim of this study was to evaluate the appropriate antibiotic administration by general practitioner in the emergency department of a teaching hospital (Tohid Hospital) in Sanandaj, Iran.Material and Methods: In this prospective descriptive study we evaluated the prescriptions for 170 patients who had been referring to the emergency department of Tohid Hospital in Sanandaj from May 2013 to May 2014. We selected 14 to 15 patients every month in a period of one year. After examination and writing prescriptions by the general practitioner, the patients were re-examined by an infectious diseases specialist. Finally, general practitioners and infectious diseases specialist's prescriptions data were recorded and compared with each other in regard to age, gender and prescribed drugs. Using spss v.18 software the data were analyzed by descriptive statistics.Results: Among 170 patients, 52.4% (89) were male and 47.6% (81) were female with an average age of 39.86±15.44 years. According to the results of this study, 11.18% of patients who had received antibiotics prescribed by the general practitioner did not require antibiotics. The exact compatibility and similarity of the prescribed antibiotics by the general practitioner and infectious diseases specialist for a specific patient was 7.8%. The mean numbers of the drugs prescribed by general practitioner and infectious diseases specialist was 2.08 and 2.21, respectively. The most common prescribed antibiotics by the infectious diseases specialist and general practitioner were ciprofloxacin (13.3%) and azithromycin (13.3%). Ciprofloxacin (21.3%) and cefixime (12%) were the most common antibiotics prescribed by the general practitioner.Conclusion: The findings of this study showed necessity of educational programs for general practitioners about antibiotic prescription.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    73-84
Measures: 
  • Citations: 

    0
  • Views: 

    783
  • Downloads: 

    0
Abstract: 

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice.Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader.Results: Barnes maze test results showed that the time and distance to reach the target hole were significantly (p<0.001) increased in the stress group. Also, the number of errors and anxiety-like behavior in the stress group were significantly (p<0.001) increased compared to those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05) higher in the control group.Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in spatial memory disorder and anxietylike behavior.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    85-91
Measures: 
  • Citations: 

    0
  • Views: 

    669
  • Downloads: 

    0
Abstract: 

Background and Aim: Considering the importance of sepsis and its complications in the mortality of the patients admitted to different parts of hospital and the importance of early diagnosis and timely and appropriate treatment in the patients' survival, we investigated the value of procalcitonin serum level for the differential diagnosis between infectious and noninfectious SIRS in the patients referring to Tohid Hospital in Sanandaj.Material and Methods: In this descriptive analytical (case-control) study, we measured procalcitonin level in SIRS positive patients who had been referring to Tohid Hospital in Sanandaj. After obtaing the results of the lab.tests the patients were divided into two groups of infectious SIRS (case group) and non-infectious (control group) based on the final diagnosis made by our infectious diseases specialist. Patients with history of antibiotic intake within the last 48 hours, mechanical trauma, heat stroke, recent surgery, cancer and severe burn were excluded from the study. Each group consisted of 30 patients. Using SPSS software, data were analyzed by independent T-test to compare the quantitative data between the two groups. We also used Pearson correlation test to investigate the relationship between procalcitonin serum level and variables related to vital signs and blood markers. P<0.05 was considered significant.Results: Mean procalcitonin serum level in the case group was significantly higher than that in the control group, and the patients with higher respiratory rate and higher WBC counts had significant increase in procalcitonin serum level. Results of this study showed that the sensitivity, specificity and accuracy of procalcitonin test at the threshold of 0.52 ng / ml were 70%, 94% and 81.7%, respectively, and positive and negative predictive values were 75.7% and 91.3%, respectively.Conclusion: According to the results, procalcitonin level had a significant sensitivity and specificity in the differential diagnosis between infectious and non-infectious SIRS and can be considered as a diagnostic test along with other clinical and paraclinical criteria in the early stages of these disorders. This can be helpful in making early diagnosis and timely administration of medications.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Author(s): 

GHOMIAN N. | MOEINDARBARI S.

Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    92-97
Measures: 
  • Citations: 

    0
  • Views: 

    501
  • Downloads: 

    0
Abstract: 

Background and Aim: Ovarian torsion is one of the rare causes of emergency surgeries during pregnancy. Heterotopic pregnancy is a rare type of pregnancy characterized by embryo implantation in two different locations. occurence of these two complications at the same time is a very rare condition. In this study, we present a rare case of heterotopic pregnancy accompanied by ovarian torsion.Patient presentation: A 33-year-old woman with fourth pregnancy presented with abdominal pain and spotting. Based on the last menstrual period, the gestational age was estimated as 7 weeks and 4 days. Ultrasound results revealed a heterotopic pregnancy with a live embryo in the uterus, a live embryo in the fallopian tube, and abundant fluid in the abdomen. Because of the patient’s unstable vital signs, she was operated and we detected a ruptured right tubal pregnancy with a 5 cm ovarian cyst on the same side and two-folded adnexal torsion. Resolution of the torsion, right salpingectomy and removal of the ovarian cyst were performed. Two days after the operation, the intrauterine embryo had no sign of heart activity; therefore, two doses of misoprostol were prescribed for the patient and curettage was performed. The patient was discharged on the next day with a good general condition.Conclusion: The simultaneous occurance of heterotopic pregnancy and ovarian torsion is a rare condition. In these cases, early diagnosis will help to preserve the ovaries and future fertility and also at the same time, maintain the intrauterine pregnancy.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    23
  • Issue: 

    3 (95)
  • Pages: 

    98-101
Measures: 
  • Citations: 

    0
  • Views: 

    636
  • Downloads: 

    0
Abstract: 

Background and Aim: One of the main goals of blood transfusion medicine is to determine the compatibility of the blood products with the patients. Therefore, clinical and laboratory (serologic) evaluations should be done to determine the maximum compatibility (or minimum incompatibility). The most known blood groups is the ABO antigenic system and the most important of them is Rh system. Among these, the most common antigen that results in incompatibility reaction is D antigen. The occurrence of all immune hemolytic reactions in other subsets of the Rh blood group is rare. Specifically, anti-C antibody is one of the rare causes of hemolytic disease in neonates, which has been reported in the articles.Case Presentation: The patient was a 85- year- old female, who was candidate for an extensive excision of right lower limb's chronic wound. The patient required packed-cell transfusion to correct anemia before surgery. Due to incompatibility of the patient's blood with any of the same ABO and Rh blood products, the panels of all blood group antibodies were checked, which revealed positive anti-C antibody. Other antibodies were negative.Conclusions: In the patients with incompatibility with the same ABO and Rh blood products, other blood groups should also be considered in order to prevent the transfusion complications by using a product with maximum compatibility (minimum incompatibility).

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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