EFFECT OF SAMBUCUS EBULUS EXTRACT ON NEURAL STEM CELL PROLIFRATION UNDER OXIDATIVE STRESS CONDITION

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HARATIZADEH S.; EBRAHIMZADEH M.A.; NAZM BOJNORDI M.; GHASEMI HAMIDABADI H.; ABDANIPOUR A.; AKHTARI J.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:23 | Issue:3 (95) Page(s): 26-35

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Title

EFFECT OF SAMBUCUS EBULUS EXTRACT ON NEURAL STEM CELL PROLIFRATION UNDER OXIDATIVE STRESS CONDITION

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Keywords

NEURAL STEM CELLSQ2

SAMBUCUS EBULUSQ1

PROLIFERATIONQ1

SURVIVALQ1

Abstract

Background and Aim: Recently, several studies have indicated that the central nervous system has the capacity for endogenous repair. But, the PROLIFERATION capacity of endogenous NEURAL STEM CELLS (NSCs) isn’t sufficient for the treatment of neurodegenerative diseases. So, it sounds that stimulation of endogenous NSC PROLIFERATION is essential for neuroregeneration. The aim of this study was to examine the effects of SAMBUCUS EBULUS extract on the PROLIFERATION of neonatal rat hippocampus-derived NEURAL STEM CELLS (NSCs) under oxidative stress condition induced by H2O2.Material and Methods: The NSCs were isolated from neonatal rat hippocampus. To confirm neural characteristics of NEURAL STEM CELLS, the expression of neural-specific marker, Nestin was investigated by immunocytochemistry technique. 5×104 cells were cultured in every well of a 96 well plate and H2O2 was added to induce oxidative stress condition. Then NSCs were exposed to 50 μg SAMBUCUS EBULUS extract for 24 hours, at various concentrations (25, 50, 100, 200, 400 and 500 mg/ml). The cell PROLIFERATION rate was assessed by MTT colorimetry assay before and after treatment with the extract.Results: Immunofluorescent studies showed that NEURAL STEM CELLS expressed specific neural marker; Nestin. The PROLIFERATION rate of NSCs increased in the treated groups in comparison to that in the control group. The highest rate of SURVIVAL was observed when SAMBUCUS EBULUS was used at the concentration of 500 mg/ml. (P<0.05).Conclusion: The results showed that the methanolic extract of SAMBUCUS EBULUS can promote PROLIFERATION and SURVIVAL of NCSs in vitro and also after exposure to oxidative stress condition, suggesting its potential beneficial effect on neuroregeneration.

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APA: Copy

HARATIZADEH, S., EBRAHIMZADEH, M.A., NAZM BOJNORDI, M., GHASEMI HAMIDABADI, H., ABDANIPOUR, A., & AKHTARI, J.. (2018). EFFECT OF SAMBUCUS EBULUS EXTRACT ON NEURAL STEM CELL PROLIFRATION UNDER OXIDATIVE STRESS CONDITION. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(3 (95) ), 26-35. SID. https://sid.ir/paper/76607/en

Vancouver: Copy

HARATIZADEH S., EBRAHIMZADEH M.A., NAZM BOJNORDI M., GHASEMI HAMIDABADI H., ABDANIPOUR A., AKHTARI J.. EFFECT OF SAMBUCUS EBULUS EXTRACT ON NEURAL STEM CELL PROLIFRATION UNDER OXIDATIVE STRESS CONDITION. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(3 (95) ):26-35. Available from: https://sid.ir/paper/76607/en

IEEE: Copy

S. HARATIZADEH, M.A. EBRAHIMZADEH, M. NAZM BOJNORDI, H. GHASEMI HAMIDABADI, A. ABDANIPOUR, and J. AKHTARI, “EFFECT OF SAMBUCUS EBULUS EXTRACT ON NEURAL STEM CELL PROLIFRATION UNDER OXIDATIVE STRESS CONDITION,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 3 (95) , pp. 26–35, 2018, [Online]. Available: https://sid.ir/paper/76607/en

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