EFFECT OF PRENATAL IMMOBILIZATION STRESS ON SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR AND BRAIN BDNF CONCENTRATION IN THE F1 GENERATION MALE MICE

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ALIABADI N.; SAHRAEI H.; BAHARI Z.; MEFTAHI G.H.

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Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:23 | Issue:3 (95) Page(s): 73-84

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Title

EFFECT OF PRENATAL IMMOBILIZATION STRESS ON SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR AND BRAIN BDNF CONCENTRATION IN THE F1 GENERATION MALE MICE

Author(s)

ALIABADI N. | SAHRAEI H. | BAHARI Z. | MEFTAHI G.H. | Issue Writer Certificate

Keywords

RESTRAINT STRESSQ2

BARNES MAZEQ1

SPATIAL MEMORYQ2

ANXIETY-LIKE BEHAVIORQ1

BDNFQ1

Abstract

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR and brain BDNF level in F1 generation male NMRI mice.Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for SPATIAL MEMORY using BARNES MAZE and ANXIETY-LIKE BEHAVIOR by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader.Results: BARNES MAZE test results showed that the time and distance to reach the target hole were significantly (p<0.001) increased in the stress group. Also, the number of errors and ANXIETY-LIKE BEHAVIOR in the stress group were significantly (p<0.001) increased compared to those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05) higher in the control group.Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in SPATIAL MEMORY disorder and anxietylike behavior.

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APA: Copy

ALIABADI, N., SAHRAEI, H., BAHARI, Z., & MEFTAHI, G.H.. (2018). EFFECT OF PRENATAL IMMOBILIZATION STRESS ON SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR AND BRAIN BDNF CONCENTRATION IN THE F1 GENERATION MALE MICE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(3 (95) ), 73-84. SID. https://sid.ir/paper/76609/en

Vancouver: Copy

ALIABADI N., SAHRAEI H., BAHARI Z., MEFTAHI G.H.. EFFECT OF PRENATAL IMMOBILIZATION STRESS ON SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR AND BRAIN BDNF CONCENTRATION IN THE F1 GENERATION MALE MICE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(3 (95) ):73-84. Available from: https://sid.ir/paper/76609/en

IEEE: Copy

N. ALIABADI, H. SAHRAEI, Z. BAHARI, and G.H. MEFTAHI, “EFFECT OF PRENATAL IMMOBILIZATION STRESS ON SPATIAL MEMORY, ANXIETY-LIKE BEHAVIOR AND BRAIN BDNF CONCENTRATION IN THE F1 GENERATION MALE MICE,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 3 (95) , pp. 73–84, 2018, [Online]. Available: https://sid.ir/paper/76609/en

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