In this study, the blood flow domain inside the diaphragm-type Ventricular Assist Device has been analyzed using numerical Fluid-Structure Interaction method. In the performed analysis, the motion and deformation of the diaphragm, the interaction of blood with the diaphragm and leaflet of valves, the control of opening and closing of the inlet and outlet valves, and also the contact of the valves leaflet with the seats were taken into the account. The blood and driving fluid were modeled as viscous, Newtonian and isothermal, and their flow was also assumed to be laminar. Because of the presence of pulsatile flow, analysis type for fluid and solid domains was the transient dynamic. The results show that during the complete cardiovascular cycle, some wakes appear inside the blood chamber and around the inlet and outlet channels, which generally formed during the diastolic phase. In the systolic phase, these wakes continually move toward the outlet channel and finally, they go to the cardiovascular circulation system.