EVALUATION OF CHONDROCYTE BEHAVIOR ON POLYVINYL ALCOHOL HYDROGELS CROSSLINKED BY URETHANE CHAINS

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BONAKDAR SHAHIN; HOJJATI EMAMI SHAHRIAR; SHOKRGOZAR MOHAMMAD ALI; HOSHIAR AHMADI SEYED AMIR

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Journal: AMIRKABIR Year:2009 | Volume:20 | Issue:70-A Page(s): 11-18

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Title

EVALUATION OF CHONDROCYTE BEHAVIOR ON POLYVINYL ALCOHOL HYDROGELS CROSSLINKED BY URETHANE CHAINS

Author(s)

BONAKDAR SHAHIN | HOJJATI EMAMI SHAHRIAR | SHOKRGOZAR MOHAMMAD ALI | HOSHIAR AHMADI SEYED AMIR | Issue Writer Certificate

Keywords

POLYVINYL ALCOHOL HYDROGELQ3

URETHANEQ3

CHONDROCYTEQ3

CARTILAGE REPLACEMENTQ3

BIOCOMPATIBILITYQ3

Abstract

Polyvinyl alcohol (PVA) hydrogels were crosslinked by different molecular weight of diisocyanate chains (168, 2400 and 6000 glmol) in order to profit from the physical-chemical advantages of both PVA hydrogels and URETHANE groups. Fourier transform infrared spectroscopy employed to confirm URETHANE formation and the absence of the isocyanate peaks (NCO) at 2270 em-1. With increasing crosslinker chain length, water uptake reduced from 450% for PVA to 120% and the ultimate tensile strength increased from 34 MPa to 54 MPa. The cell viability evaluated by 3- (4, 5-DimethyIthiazol-2-yl) -2, 5-diphenyItetrazolium bromide (MIT) assay on rabbit isolated CHONDROCYTEs. In addition, the amounts of proteoglycan secreted by cells in the vicinity of the samples were assessed by dimethyl methylene blue staining protocol which confirmed the highest level for sample 3. The spherical morphology of the isolated cells on the samples verified with scanning electron microscopy (SEM). It can be concluded that crosslinking of the PVA with polyurethane chains (6000 glmol) may consider as a suitable candidate for natural CARTILAGE REPLACEMENT.

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APA: Copy

BONAKDAR, SHAHIN, HOJJATI EMAMI, SHAHRIAR, SHOKRGOZAR, MOHAMMAD ALI, & HOSHIAR AHMADI, SEYED AMIR. (2009). EVALUATION OF CHONDROCYTE BEHAVIOR ON POLYVINYL ALCOHOL HYDROGELS CROSSLINKED BY URETHANE CHAINS. AMIRKABIR, 20(70-A), 11-18. SID. https://sid.ir/paper/872/en

Vancouver: Copy

BONAKDAR SHAHIN, HOJJATI EMAMI SHAHRIAR, SHOKRGOZAR MOHAMMAD ALI, HOSHIAR AHMADI SEYED AMIR. EVALUATION OF CHONDROCYTE BEHAVIOR ON POLYVINYL ALCOHOL HYDROGELS CROSSLINKED BY URETHANE CHAINS. AMIRKABIR[Internet]. 2009;20(70-A):11-18. Available from: https://sid.ir/paper/872/en

IEEE: Copy

SHAHIN BONAKDAR, SHAHRIAR HOJJATI EMAMI, MOHAMMAD ALI SHOKRGOZAR, and SEYED AMIR HOSHIAR AHMADI, “EVALUATION OF CHONDROCYTE BEHAVIOR ON POLYVINYL ALCOHOL HYDROGELS CROSSLINKED BY URETHANE CHAINS,” AMIRKABIR, vol. 20, no. 70-A, pp. 11–18, 2009, [Online]. Available: https://sid.ir/paper/872/en

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